10-吲哚细胞松弛素chaetoglobosin F的NMR解析

doi:10.11938/cjmr20182672

波谱学杂志 ›› 2019, Vol. 36 ›› Issue (1): 74-82.doi: 10.11938/cjmr20182672

10-吲哚细胞松弛素chaetoglobosin F的NMR解析

尹田鹏¹, 汪泽¹, 陈阳¹, 邵娅婷², 邓亮², 黎唯²

1. 遵义医科大学珠海校区, 珠海市中药基础及应用研究重点实验室, 广东珠海 519041;
2. 昆明医科大学药学院, 云南省天然药物药理重点实验室, 云南昆明 620500

收稿日期:2018-08-02 出版日期:2019-03-05 发布日期:2018-09-03
通讯作者: 黎唯,Tel:0871-65922871;E-mail:liwei@kmmu.edu.cn E-mail:liwei@kmmu.edu.cn
基金资助:
遵义市科技计划课题[遵市科合社字（2017）05号]；云南省科技厅-昆明医科大学应用基础研究联合专项资金资助项目[2017FE468（-136）].

An NMR Analysis of 10-Indol Cytochalasin Chaetoglobosin F

YIN Tian-peng¹, WANG Ze¹, CHEN Yang¹, SHAO Ya-ting², DENG Liang², LI Wei²

1. Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, China;
2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 620500, China

Received:2018-08-02 Online:2019-03-05 Published:2018-09-03

摘要/Abstract

摘要： 源于真菌的天然产物细胞松弛素类化合物（cytochalasins）是微生物研究的热点领域之一．该类化合物结构复杂多样，核磁共振（NMR）波谱鉴定困难．Chaetoglobosin F是分离自五加科药用植物三七（Panax notoginseng）种子内生真菌Chaetomium globosum中的10-吲哚类细胞松弛素．本文对chaetoglobosin F进行NMR结构解析及数据归属，并总结归纳10-吲哚类细胞松弛素的NMR特征，为该类化合物的深入研究提供参考．

关键词: 细胞松弛素, chaetoglobosin F, 吲哚, 核磁共振(NMR), 结构鉴定

Abstract: Cytochalasins are a group of natural products from fungus, and have been attracting lots of research interests in the field of microbiology. Cytochalasins possess complex and diverse structures, making nuclear magnetic resonance (NMR) based structure elucidation difficult. Chaetoglobosin F is a 10-indol cytochalasin isolated from endophytic Chaetomium globosum growing in the seeds of Panax notoginseng. This paper reported the NMR data chaetoglobosin F, along with the summarization of NMR features of 10-indol cytochalasins, providing a good reference for the further research on cytochalasins.

Key words: cytochalasins, chaetoglobosin F, indol, nuclear magnetic resonance (NMR), structural elucidation

中图分类号:

O482.53

尹田鹏, 汪泽, 陈阳, 邵娅婷, 邓亮, 黎唯. 10-吲哚细胞松弛素chaetoglobosin F的NMR解析[J]. 波谱学杂志, 2019, 36(1): 74-82.

YIN Tian-peng, WANG Ze, CHEN Yang, SHAO Ya-ting, DENG Liang, LI Wei. An NMR Analysis of 10-Indol Cytochalasin Chaetoglobosin F[J]. Chinese Journal of Magnetic Resonance, 2019, 36(1): 74-82.

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10-吲哚细胞松弛素chaetoglobosin F的NMR解析

An NMR Analysis of 10-Indol Cytochalasin Chaetoglobosin F

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