波谱学杂志 ›› 2016, Vol. 33 ›› Issue (2): 353-359.doi: 10.11938/cjmr20160217

• 研究简报 • 上一篇    

洛莫司汀的1H、13C NMR全归属

孙伟, 高翔, 郭娟, 余向阳   

  1. 西北大学 化学与材料科学学院, 合成与天然功能分子化学教育部重点实验室, 陕西 西安 710127
  • 收稿日期:2015-05-19 修回日期:2016-04-15 出版日期:2016-06-05 发布日期:2016-06-05
  • 通讯作者: 孙伟,电话:029-81535028,E-mail:sunw817@nwu.edu.cn. E-mail:sunw817@nwu.edu.cn
  • 作者简介:孙伟(1979-),男,甘肃兰州人,工程师,有机分析专业.
  • 基金资助:

    陕西省自然科学基金资助项目(2010JM2001).

An NMR Study on Lomustine

SUN Wei, GAO Xiang, GUO Juan, YU Xiang-yang   

  1. Key Laboratory of Synthetic and Natural Functional Molecular Chemistry, Ministry of Education, College of Chemistry & Material Science, Northwest University, Xi'an 710127, China
  • Received:2015-05-19 Revised:2016-04-15 Online:2016-06-05 Published:2016-06-05

摘要:

应用1H NMR、13C NMR、DEPT135、1H-13C HMBC、1H-13C HSQC、1H-1H COSY和1H-1H NOESY等多种NMR技术,对文献报道的洛莫司汀(Lomustine)1H和13C NMR数据进行了修正与补充;特别是应用2D NMR对重叠程度较高的环己烷区进行了指认归属,并确定了其空间构型.

关键词: 核磁共振(NMR), 结构归属, 洛莫司汀

Abstract:

Lomustine is an important drug having chiral carbon atoms. In the present study, one-dimensional 1H and 13C NMR, as well as two-dimensional techniques (i.e., 1H-13C HMBC, 1H-13C HSQC, 1H-1H COSY and 1H-1H NOESY) were used to elucidate the structure of Lomustine. The proton and carbon chemical shifts of the compound were assigned.

Key words: NMR, assignment, Lomustine

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