卷柏属Selaginellin类化合物互变异构的波谱学研究

doi:10.11938/cjmr20182683

波谱学杂志 ›› 2019, Vol. 36 ›› Issue (2): 155-163.doi: 10.11938/cjmr20182683

卷柏属Selaginellin类化合物互变异构的波谱学研究

曹园¹, 吴永平², 陈东军³

1. 南京中医药大学附属医院, 药学部, 江苏南京 210036;
2. 江苏省药物研究所, 江苏南京 210009;
3. 中国药科大学, 分析测试中心, 江苏南京 210009

收稿日期:2018-09-13 发布日期:2018-11-11
通讯作者: 曹园 Tel:025-86529291, E-mail:caoy2002@126.com E-mail:caoy2002@126.com
基金资助:
the National Natural Science Foundation of China (81102772).

A Spectroscopic Study on Tautomerism of Selaginellins from Selaginella

CAO Yuan¹, WU Yong-ping², CHEN Dong-jun³

1. Department of Pharmacy, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210036, China;
2. Jiangsu Provincial Institute of Materia Medica, Nanjing 210009, China;
3. Center for Instrument Analysis, China Pharmaceutical University, Nanjing 210009, China

Received:2018-09-13 Published:2018-11-11
Supported by:
the National Natural Science Foundation of China (81102772).

摘要/Abstract

摘要： 本文采用紫外可见吸收光谱和核磁共振波谱等方法研究了pH、溶剂及温度对卷柏属植物中selaginellin类化合物互变异构的影响.实验结果表明：酸性、碱性及质子化溶剂可以催化selaginellin类化合物的互变异构；变温核磁共振技术证实温度低于233K时，selaginellin类化合物的互变异构几乎被阻断.

关键词: 核磁共振(NMR), 紫外可见光吸收光谱, selaginellin, 互变异构

Abstract: Ultraviolet-visible and nuclear magnetic resonance (NMR) spectroscopy was used to investigate the effects of pH, solvent and temperature on the tautomeric equilibrium of selaginellins from Selaginella. The results demonstrated that the tautomerism of selaginellins could be catalyzed by acid, base and protic solvent. Variable-temperature ¹H NMR experiments demonstrated that the tautomerism was interrupted when the temperature fell below 233 K.

Key words: nuclear magnetic resonance (NMR), ultraviolet-visible absorption spectrum, selaginellin, tautomerism

中图分类号:

O482.53

曹园, 吴永平, 陈东军. 卷柏属Selaginellin类化合物互变异构的波谱学研究[J]. 波谱学杂志, 2019, 36(2): 155-163.

CAO Yuan, WU Yong-ping, CHEN Dong-jun. A Spectroscopic Study on Tautomerism of Selaginellins from Selaginella[J]. Chinese Journal of Magnetic Resonance, 2019, 36(2): 155-163.

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卷柏属Selaginellin类化合物互变异构的波谱学研究

A Spectroscopic Study on Tautomerism of Selaginellins from Selaginella

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