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Progresses on Low-Rank Reconstruction for Non-Uniformly Sampled NMR Spectra
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ZHAN Jia-ying, TU Zhang-ren, DU Xiao-feng, YUAN Bin, GUO Di, QU Xiao-bo
Chinese Journal of Magnetic Resonance, 2020, 37(3): 255-272.
DOI: 10.11938/cjmr20202816
Multidimensional nuclear magnetic resonance (NMR) spectroscopy is frequently used to analyze molecular structures, and widely applied in researches in the fields of chemistry, biology and medicine. However, data acquisition time increases rapidly with increasing spectral dimension and number of sampling points. Non-uniformly sampling (NUS) can speed up data acquisition by reducing the amount of sampling data in the indirect dimensions, while obtaining a complete spectrum with proper reconstruction methods. How to achieve faster sampling and better reconstruction of a high-quality spectrum are important problems in multidimensional NMR. This article reviews the recent progresses on the low-rank NMR spectra reconstruction methods. First, the related mathematical basics of low-rank matrices are introduced. Then, the spectra reconstruction models are discussed from two perspectives:general low-rank matrix and structured low-rank Hankel matrix. Finally, the limitations and future trends of these methods are discussed.
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A Design Scheme for 1 H/31 P Dual-Nuclear Parallel MRI Coil
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LIAO Zhi-wen, CHEN Jun-fei, YANG Chun-sheng, ZHANG Zhi, CHEN Li, XIAO Li-zhi, CHEN Fang, LIU Chao-yang
Chinese Journal of Magnetic Resonance, 2020, 37(3): 273-282.
DOI: 10.11938/cjmr20192737
Based on the principle of birdcage coil and the decoupling theory of array coil, a design scheme for dual-nuclear magnetic resonance imaging (MRI) coil is proposed. A LC parallel trap is used to improve the adaptability of the inductive decoupling scheme. According to the design scheme and simulation, a 1 H/31 P dual-nuclear parallel MRI coil is fabricated for a 4.7 T system. Dual-nuclear parallel imaging experiments are carried out on a custom-built MRI system to verify the feasibility of the coil design.
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Structure and Configuration Analyses of a Nucleating Agent for Isotactic Polypropylene Crystallization
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WEN Liang, LI Chun-fa
Chinese Journal of Magnetic Resonance, 2020, 37(3): 291-299.
DOI: 10.11938/cjmr20192763
The nucleating agent acts as a crystal nucleus during polypropylene (PP) crystallization, affecting the structure and size distribution of the crystal, and in turn the properties of PP products. It is a hot research topic to study the mechanisms by which the nucleating agent promotes polymer crystallization. Currently it is still unclear how the structure of nucleating agent affects polymer crystallization. In addition, a nucleating agent may have different chemical structures due to isomerization, further complicating the nucleation mechanism study. Structural studies of nucleating agents are therefore the foundation of the nucleation mechanism studies. In this work, the structure and configuration of a β nucleating agent used in PP crystallization were studied by the combination of nuclear magnetic resonance (NMR) spectroscopy, Fourier transform-infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS). The FT-IR data suggested that the chelating way of calcium salt of cis -Δ 4-tetrahydrophthalic acid in the nucleating agent belongs to the bridge type, while the cis -Δ 4-tetrahydrophthalic acid is a mesomer.
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Classification of Alzheimer's Disease Patients Based on Magnetic Resonance Images and an Improved UNet++ Model
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ZHAO Shang-yi, WANG Yuan-jun
Chinese Journal of Magnetic Resonance, 2020, 37(3): 321-331.
DOI: 10.11938/cjmr20192769
Alzheimer's disease (AD) is one of the most common forms of dementia and a degenerative mental disorder that seriously affects people's daily lives. Rapid and effective diagnosis is essential for the treatment of patients with Alzheimer's disease. To solve this problem, this paper proposes a deep convolutional neural network structure with multiple semantic levels to classify AD patients and healthy controls from magnetic resonance imaging (MRI) data. Firstly, the deep supervision integration algorithm and the classification model of Alzheimer's disease based on the traditional UNet++ network were improved. Then, a new feature fusion structure was constructed, which further refined the different semantic levels. Lastly, the proposed protocol was applied to different tissue regions (e.g., white matter, gray matter and cerebrospinal fluid), and the effects of different tissue information combinations on the classification outcome were explored. The method proposed was applied to the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset to classify the AD patients. The results demonstrated that the highest accuracy of 98.74%, and an average accuracy of 98.47%.
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Effects of Panax quinquefolius L.-Acorus Tatarinowii on Cognitive Deficits and Brain Morphology of Type 1 Diabetic Rats
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ZHOU You, YANG Yang, SONG Li-qiang, BI Tian-tian, WANG Yue, ZHAO Ying
Chinese Journal of Magnetic Resonance, 2020, 37(3): 332-348.
DOI: 10.11938/cjmr20192738
This study explored the effects of Panax quinquefolius L.-Acorus Tatarinowii (X-S) on learning and memory behaviors and related brain regions in rats with diabetes-associated cognitive decline (DACD). Type 1 diabetes mellitus (DM) was induced by intraperitoneal injection of streptozotocin (STZ). The DM rats were randomly divided into the DM group and X-S group. Starting at day 7 after the STZ induction, X-S was administered once a day for 113 consecutive days. Morris water maze test was performed to screen the DM rats with and without cognitive impairment at 80 days after the STZ induction. The volume and concentration of gray matter and white matter in the whole brain were analyzed from magnetic resonance imaging (MRI) data acquired at day 120 after the STZ induction, with a region of interest (ROI)-based method and voxel-based morphometry (VBM). Hippocampal neurons were stained with hematoxylin and eosin (HE). The results of ROI-based analysis showed that:the volume of left temporal association cortex of the X-S rats decreased significantly (p <0.05), compared with the DACD rats. The VBM results showed that:the volume or concentration of CA1, CA3 and other brain regions increased or decreased in the X-S rats (p <0.005), compared with the DACD rats. The HE staining results showed that:X-S treatment alleviated cell pyknosis of the CA1 and CA3 neurons. It was concluded that X-S treatment has both positive and negative effects on the hippocampus and other brain areas related to learning and memory in the DACD rats.
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Evaluation of Core Samples from Low-Porosity and Low-Permeability Carbonate Reservoir with NMR Experiments
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ZHU Xue-juan, ZHANG Xiang-ming, SHAN Sha-sha
Chinese Journal of Magnetic Resonance, 2020, 37(3): 349-359.
DOI: 10.11938/cjmr20192741
Well logging evaluation of the low-porosity and low-permeability carbonate reservoir is difficult because of its complex mineral composition, difficult to determine rock skeleton parameters, diverse types of reservoir space, complex pore structure and pore-permeability relationship, and unobvious response characteristics of conventional logging curves. In order to quantitatively evaluate the pore structure and calculate the reservoir parameters by nuclear magnetic resonance (NMR) logging, NMR experiments on the core samples from low-porosity and low-permeability reservoir were performed. The pore structure was analyzed from the NMR data, and a T 2 cutoff value was calculated using the T 2 spectrum distribution curve. With the NMR method, the total porosity, effective porosity, bound water porosity, permeability and other reservoir parameters of the core samples were determined and compared with the results obtained with the conventional core experiments. The advantages and limitations of NMR methods in evaluating the low-porosity and low-permeability reservoirs were summarized.
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A Two-Dimensional NMR Logging Method for Gas-Water Identification in Dolomite Reservoir of the Western Sichuan Gas Field
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ZHANG Shi-mao, GE Xiang, WANG Xin, HOU Ke-jun
Chinese Journal of Magnetic Resonance, 2020, 37(3): 360-369.
DOI: 10.11938/cjmr20192754
The dolomite reservoirs in the fourth member of Leikoupo formation of the western Sichuan gas field have good prospects for natural gas exploration and development. However, the conventional and one-dimensional nuclear magnetic resonance (1D NMR) logging data are not sufficient for a definitive classification of the reservoir fluid type, likely because of heterogeneity of the reservoirs. Through geological characteristics analysis, log response analysis and two-dimensional (2D) NMR experiment, the environmental factors and technical parameters leading to the differences between the laboratory results and actual logging data were determined. According to the analysis of T 2 -T 1 and T 1 /T 2 (R ) differences, the distribution range of drilling fluid, bound fluid, movable water and natural gas signals in the 2D NMR spectra was delineated to build a gas-water 2D NMR identification chart. The results obtained using the identification chart were verified with the actual drilling test results. Complementary to conventional and 1D NMR logging, the 2D NMR identification method was proposed, and can be used to determine the fluid properties in the dolomite reservoirs effectively.
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Factors Affecting and Correction Methods for Porosity Measured by NMR Logging in the J Oilfield of Bohai Bay
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LIU Huan, XU Jin-xiu, ZHENG Yang, XIONG Lei
Chinese Journal of Magnetic Resonance, 2020, 37(3): 370-380.
DOI: 10.11938/cjmr20192770
The porosity of reservoir bed and core in the Shahejie formation of the J oilfield of Bohai bay measured by nuclear magnetic resonance (NMR) logging were found to be lower than those measured by the reference helium method, affecting the application of NMR logging. NMR experiments on the core samples were performed to study the contributions of potential affecting factors, including instrument acquisition parameters, wellbore environment and reservoir fluid properties. The main reason for the lower porosity measured by NMR logging was found to be the intrusion of high salinity mud filtrate. The effects of brines with different salinity on NMR T 2 spectrum were analyzed, and the results were used to determine the lower limit of salinity required for morphological correction of the NMR T 2 spectrum. In view of that the intrusion of high salinity mud filtrate could affect the NMR T 2 spectrum during actual logging, a model for morphological correction of the NMR T 2 spectrum and a method to correct the NMR porosity at different salinity were established. The experimental results demonstrated that the average relative error of the NMR porosity reduced from 13.56% to 2.81% after correction.
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A Review on Spectral Characteristics of Dendrobines from the Dendrobium Plants
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YIN Tian-peng, LI Xing, WANG Ze, WANG Ya-rong, WANG Min
Chinese Journal of Magnetic Resonance, 2020, 37(3): 381-389.
DOI: 10.11938/cjmr20192757
Dendrobine-type sesquiterpenoid alkaloids from the Dendrobium plants have attracted many research interests due to their unique structures and remarkable physiological activities. This paper reviews the structural features and spectral (i.e., ultraviolet, infrared, mass and NMR) characteristics of dendrobines, and how their structures could be elucidated from the spectral data. The present work may provide a reference for further research and development of dendrobines.
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NMR Assignments of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine
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WANG Si-hong, ZHANG Jing-dong, YIN Xiu-mei, LI Dong-hao, KAN Yu-he, HU Wei
Chinese Journal of Magnetic Resonance, 2020, 37(3): 390-398.
DOI: 10.11938/cjmr20192776
6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine is a national class I innovative antiepileptic drug candidate in clinical trials with independent intellectual property rights. The 1 H, 13 C and 15 N NMR spectra of the compound were acquired at 500 MHz. Aided by GIAO (Gauge-Independent Atomic Orbital)-NMR quantum chemistry calculation, the chemical shifts of the compound were assigned, providing elaborate structural information of the compound. Linear regression comparison results showed good consistency between the theoretical predictions and the experimental data for structural elucidations.