Studies of NMR Quantitative Analysis for Water-Soluble Vitamins

Abstract

Abstract:

NMR quantitative analysis of drug is the method with simple operation and use just a few amount of samples. The method can accomplish the qualitative as well as the quantitative analysis simultaneously，and do not need any standard compound but only the common internal standard for the quantitative analysis. The analysis speed and the precision of the method is close to the HPLC method. In this paper，the results of determination for water-soluble vitamin by NMR quantitative analysis with chemical analysis have been compared .The experiment shows the results of the NMR quantitative analysis are coincident with the result of the chemical method. Therefore，the NMR quantitative analysis method can be used market regulation of drugs.

Key words: NMR, quantitative analysis, , water-soluble vitamins, Chinese Pharmacopoeia

CLC Number:

O482.53

ZHANG Ye, LIU Xiao-Peng, ZHANG You-Jie. Studies of NMR Quantitative Analysis for Water-Soluble Vitamins[J]. Chinese Journal of Magnetic Resonance, 2011, 28(3): 357-365.

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