Chinese Journal of Magnetic Resonance ›› 2021, Vol. 38 ›› Issue (2): 255-267.doi: 10.11938/cjmr20202840

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Nuclear Magnetic Resonance Assignment and Crystal Structure of 3, 22-Dihydroxyhopane

Lei JIANG1,Yang FU1,Wen-wen GUO2,Guo ZHENG1,Qiang WANG1,2,*()   

  1. 1. High and New Technology Research Center of Henan Academy of Sciences, Zhengzhou 450002, China
    2. Henan Institute of Reproductive Health Science and Technology, Zhengzhou 450002, China
  • Received:2020-06-29 Online:2021-06-05 Published:2020-08-27
  • Contact: Qiang WANG E-mail:wangqiangno1@hotmail.com

Abstract:

Pure α- and β- isomers of 3, 22-dihydroxyhopane were obtained by the reduction of hydroxyl protected hydroxyhopanone with L-selectride. The absolute configuration of 3β, 22-hydroxyhopane was confirmed by single crystal X-ray diffraction, and the unambiguous 1H and 13C NMR data of two isomers were fully assigned for the first time. The preparation method is suitable for the separation of other unseparated α, β-isomers.

Key words: 3, 22-dihydroxyhopane, 1H NMR, 13C NMR, absolute configuration

CLC Number: