Spectroscopic Studies and Structural Elucidation of Cabazitaxel

doi:10.11938/cjmr20170208

Abstract

Abstract: Infrared, ultraviolet, NMR (i.e., ¹H NMR, ¹³C NMR, DEPT-135, COSY, HSQC and HMBC), and mass spectroscopic data of cabazitaxel were collected and interpreted. Differential thermal analysis, X-ray power diffraction and elementary analysis were also used to characterize the compound. All ¹H and ¹³C NMR signals were assigned. Possible fragmentation pathways were discussed based on the information provided by the mass spectra. The infrared spectrum was used to analyze the types of vibration of the functional groups in the compound. The structure of the compound was determined.

Key words: cabazitaxel, infrared spectroscopy, structural elucidation, NMR, mass spectroscopy

CLC Number:

O482.53

YU Da-hai, KANG Wang, HAO Fu, LI Zhi-gang. Spectroscopic Studies and Structural Elucidation of Cabazitaxel[J]. Chinese Journal of Magnetic Resonance, 2017, 34(2): 191-199.

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