Metabonomics Analysis of Brown Adipose and White Adipose Tissues

doi:10.11938/cjmr20160204

Abstract

Abstract:

Brown adipose tissue (BAT) plays a vital role in energy metabolism, and has been regarded as a novel potential drug target for treating obesity. However, the metabolic compositions of BAT and white adipose tissue (WAT) remain to be determined. We applied nuclear magnetic resonance (NMR) and gas chromatography (GC) based metabonomics approaches to characterize and compare the composition of water-soluble metabolites and fatty acids in BAT and WAT. The results indicated that these two types of adipose tissue have marked differences in carbohydrate metabolism, amino acid metabolism, fatty acids metabolism, nucleotide metabolism and choline metabolism pathways, and these differences are tightly associated with their unique biological functions. Our research provided clues and basic information for elucidation of the function of BAT at molecular level.

Key words: nuclear magnetic resonance (NMR), gas chromatography (GC), metabonomics, fatty acids, brown adipose tissue (BAT), white adipose tissue (WAT)

CLC Number:

O482.53

SONG Yi-peng, LI Ning, XUE Hai-si, LI Jing, WANG Yu-lan. Metabonomics Analysis of Brown Adipose and White Adipose Tissues[J]. Chinese Journal of Magnetic Resonance, 2016, 33(2): 208-223.

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