Chinese Journal of Magnetic Resonance

Previous Articles     Next Articles

Magnetic Resonance Molecular Imaging with Hyperpolarized 129Xe

ZHANG Ji1,2, LUO Qing1, GUO Qian-ni1, CHEN Shi-zhen1, ZHOU Xin1*   

  1. 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance (Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;
    2.  University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2012-09-07 Revised:2012-11-20 Online:2013-06-05 Published:2013-06-05
  • About author:*Corresponding author: Zhou Xin,Tel:027-87198802,E-mail: xinzhou@wipm.ac.cn.
  • Supported by:

    国家自然科学基金资助项目(81227902, 11004228);国家科学技术部创新方法资助项目(2010IM- 030600);中国科学院知识创新工程重要方向资助项目(KJCX2-EW-N06);中国科学院“百人计划”资助项目([2010]88).

Abstract:

The applications of magnetic resonance molecular imaging are often hindered  by low sensitivity. Magnetic resonance signal of hyperpolarized 129Xe can be enhanced 4~5 orders of magnitude by spin-exchange optical pumping. Ultrasensitive 129Xe magnetic resonance molecular imaging shows a huge advantage in sensitivity comparing with the conventional MRI. In this paper, the improvement of the sensitivity of MRI and its applications to scientific research are introduced; the basic structures and principle of Xe-based biosensors are interpreted; the updated methodology and technology of molecular imaging are reviewed, and the advance of magnetic resonance molecular imaging with hyperpolarized 129Xe is commented.

Key words: MRI, molecular imaging, hyperpolarized 129Xe, sensitivity, molecular sensors

CLC Number: