Chinese Journal of Magnetic Resonance ›› 2011, Vol. 28 ›› Issue (1): 127-134.

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T2-Weighted Imaging and Histological Assessment on a Transgenic APPswe/PS1dE9 Mouse Model

 XU Wei1*, ZHAN Ya-Qang2   

  1. 1. State Key Laboratory of Magnetic Resonance and Molecular and Atomic Physics, (Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;
    2. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Online:2011-03-05 Published:2011-03-05
  • Supported by:

    国家重点基础研究发展计划(“973”计划)资助项目(2006CB705600),国家自然科学基金资助项目(30870674,0921004).

Abstract:

We studied a double transgenic APPSwe/PS1dE9 mouse model using T2-weighted imaging and histological assessment to detect agerelated amyloidosis and iron load in the hippocampus and cortex. The results indicated that T2 of older transgenic mice was slightly higher than that of the younger ones, but the difference did not reach statistical significance. We also did not found any significant T2 difference between transgenic mice and age-matched non-transgenic littermates. Histological assessment revealed an age-related increase of amyloid load in the hippocampus and parietal cortex. Positive iron staining was observed in amyloid-rich regions of 16-month-old APP/PS1 mice, and co-localized, to a large extent, with amyloid deposits. These results indicated that T2 might not be sensitive enough to detect amyloid and iorn deposition in this model.

Key words: MRI, T2-weighted imaging, amyloid-β, iron load, Alzheimer’s disease

CLC Number: