Early Pathological Changes in the Optic Nerves of STZ-Treated Diabetic Rats Revealed by Directional Diffusion-Weighted MRI

Abstract

Abstract:

Type-I diabetes was induced in rats by a single injection of streptozotocin (STZ). Directional diffusion-weighted imaging on the optic nerves were performed one month later to monitor the early optic neuropathy (e.g., axonal injury and myelin sheaths damage) induced by diabetes. Water diffusivities parallel and perpendicular to the axonal tracts were measured by apparent diffusion coefficients ADC_∥ and ADC_⊥, respectively. Compared to the control animals, the STZ-treated animals showed a trend of reduced ADC_⊥ in bilateral optic nerves, but less consistent changes in ADC_∥.

Key words: MRI, diffusion, optic nerves, streptozotocin, diabetes

CLC Number:

R445.2

GAO Li-Feng, HUANG Ming-Ming, LEI Hao. Early Pathological Changes in the Optic Nerves of STZ-Treated Diabetic Rats Revealed by Directional Diffusion-Weighted MRI[J]. Chinese Journal of Magnetic Resonance, 2009, 26(4): 485-491.

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