CEREBRAL CHANGES DURING THE EARLY STAGE OF A RAT MODEL OF CHRONIC TEMPORAL EPILEPSY OBSERVED BY MAGNETIC RESONANCE IMAGING [STHZ]AND LOCALIZED IN VIVO 1H MRS

Abstract

Abstract:

In this study, MRI and localized in vivo ¹H-MRS were applied to study cerebral changes during the early stage of a rat model of chronic temporal epilepsy. Epilepsy was induced by repetitive tetanus to the right basal dendrite region. Six days after the initial tetanus, T₂-weighted MRI (T-₂W-MRI) revealed that there was a significant increase in signal intensity of the right ventral part of hippocampus, the signal intensity of the same region decreased significantly in diffusion-weighted MRI (DWI). Such changes may be caused by the increase of the ratio of free water to bounded water in the affected region. Decrease of NAA was not found in the foci of epilepsy with localized in vivo ¹H-MRS, suggesting that there existed little or no loss of neurons during the early stage of this model of temporal epilepsy.

Key words: MRI, ¹H-MRS, temporal epilepsy, brain, rat

CLC Number:

O482.53

YANG Yun-Huang, ZHANG Ying, DIAO Fang-Ming, HAN Dan, LI Li-Yun, YE Chao-Hui, LIU Mai-Li. CEREBRAL CHANGES DURING THE EARLY STAGE OF A RAT MODEL OF CHRONIC TEMPORAL EPILEPSY OBSERVED BY MAGNETIC RESONANCE IMAGING [STHZ]AND LOCALIZED IN VIVO ¹H MRS[J]. Chinese Journal of Magnetic Resonance, 2004, 21(3): 281-288.

References

[1] Gao Y G(高元桂)，Cai Y Q(蔡幼铨)，Cai Z L(蔡祖龙). Diagnostics of Nuclear Magnetic Imaging (核磁共振成像诊断学)[M]. Beijing(北京): People's Military Medical Press（人民军医出版社），1992,   P242. 

[2] Dennis S. Editorial[J]. Magn Reson Imaging, 1995,  3:  1 045.

[3] Tang X W(唐孝威).Functional Imaging of Brain(脑功能成像)[M]. Hefei（合肥）: University of Science and Technology of China Press（中国科学技术大学出版社）, 1999.

[4] Susan S, Spencer W H, Theodore, et al. Clinical applications: MRI, SPECT, and PET[J]. Magn Reson Imaging, 1995, 13: 1 119-1 124.

[5] Cendes F, Leproux F, Melanson D, et al. MRI of amygdala and hippocampus in temporal lobe epilepsy[J]. {J Comput} Assist Tomo, 1993,   17: 206-210.

[6] Cook M J, Fish D R, Shorvon S D, et al. Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy[J]. Brain,   1992, 115: 1 001-1 015.

[7] Edward J, Novotny Jr. Overview the role of NMR spectroscopy in epilepsy[J]. Magn Reson Imaging, 1995, 13: 1 171-1 173.

[8] Gadian D G. N-acetylaspartate and epilepsy[J]. Magn Reson Imaging, 1995, 13: 1 193-1 195.

[9] Zhang X R, Han D,  Tang Y F,  et al. Synaptic modification of epileptiform discharges in response to repetitive tetanus into hippocampaltemporal neocortex neural pathway and their target-behaviour expression associated with epileptic seizures in rats[J]. Chin J Neurosci, 2000,   16: 192-199.

[10] Han D, Zhang X R, Tang Y F,  et al. An investigation on the relations between synchronized oscillations and epileptogenesis induced by repeatedly delivering tetanus into the hippocampus and medial temporal neocortex in rats[J]. Chin J Neurosci,  2000, 16: 108-114.

[11] Bao X M(包新民)，Shu S Y(舒斯云). Localized Atlas of Rat Brain (大鼠脑立体定位图谱)[M]. Beijing(北京): People's Medical Publishing House（人民卫生出版社），1991.

[12] Zubler F, Seeck M, Landis T, et al. Contralateral medial temporal lobe damage in right but not left temporal lobe epilepsy: a (1)H magnetic resonance spectroscopy study[J]. J Neurol Neurosur Psychiatry, 2003，74: 1 240-1 244.

[13] Kapur N, Prevett M. Unexpected amnesia: are there lessons to be learned from cases of amnesia following unilateral temporal lobe surgery?[J]. Brain, 2003，126: 2 573-2 585.

[14] Bragin A, Wilson C L, Engel J Jr. Chronic epileptogenesis requires development of a network of pathologically in-terconnected neuron clusters: a hypothesis[J]. Epilepsia, 2000, 41: Suppl 6: S144-152.

[15] Zang Y(臧颖)，Han D(韩丹)，Yang Y H(杨运煌)，et al. Development and progression in rat brain abnormalities related to early stage of epilepsy measured by magnetic resonance image(核磁共振检测大鼠早期癫痫源性脑损伤的动态发展特征)[J]. Acta Physiol Sin(生理学报),  2002,   54: 201-207.

[16] Zhong J, Petroff O A C, Prichard J W, et al. Barbituratereversible reduction of water diffusion coefficient in flurothyl-induced status epilepticus in rats[J]. Magnet Reson Med, 1995, 33: 253-256.

[17] Righini A, Pierpaoli C,  Alger J R, et al. Brain parenchyma apparent diffusion coefficient alterations associated with experiment complex partial status epilepticus[J]. Magnet Reson Imaging, 1994, 12: 865-871.

[18] Ebisu T, Rooney W D, Graham S H, et al. MR spectroscopic imaging and diffusion-weighted MRI for early dectection of kainate-induced status epilepticus in the rat[J]. Magnet Reson Med, 1996,  36: 821-828.

CEREBRAL CHANGES DURING THE EARLY STAGE OF A RAT MODEL OF CHRONIC TEMPORAL EPILEPSY OBSERVED BY MAGNETIC RESONANCE IMAGING [STHZ]AND LOCALIZED IN VIVO ¹H MRS

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