A Novel Molecular Cage for Hyperpolarized 129Xe Based on Cucurbit[6]uril Nanoparticles

doi:10.11938/cjmr20192742

Abstract

Abstract: Hyperpolarized ¹²⁹Xe NMR has a detection sensitivity up to 10 000 times higher than that in the conventional ¹H NMR. Hyperpolarized ¹²⁹Xe gas has only one NMR signal, but can produce multiple signals when combined with molecular cages, providing the chances to develop targeted molecular probes. In this paper, water-soluble cucurbit[6]uril nanoparticles were used for loading hyperpolarized ¹²⁹Xe gas to construct targeted molecular probes. It was observed that such molecular probes had double "cage" signals and the potential to be developed into multi-functional probes.

Key words: hyperpolarized ¹²⁹Xe nuclear magnetic resonance, chemical exchange saturation transfer (CEST), nanoparticle, cucurbit[6]uril

CLC Number:

O482.53

YUAN Chen-lu, GUO Qian-ni, CHEN Shi-zhen, ZHOU Xin. A Novel Molecular Cage for Hyperpolarized ¹²⁹Xe Based on Cucurbit[6]uril Nanoparticles[J]. Chinese Journal of Magnetic Resonance, 2019, 36(4): 472-480.

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A Novel Molecular Cage for Hyperpolarized ¹²⁹Xe Based on Cucurbit[6]uril Nanoparticles

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