糖尿病脑病的磁共振研究

摘要/Abstract

摘要：

糖尿病是由胰岛素分泌不足（T1DM）或胰岛素抵抗（T2DM）而引发的慢性代谢疾病，严重影响人们的生活质量. 中枢神经系统是糖尿病并发症的易感部位. 临床研究和流行病学调查结果显示，糖尿病会引发脑白质损伤、脑萎缩和认知功能障碍，并会增加脑卒中的风险. 磁共振成像和活体磁共振波谱可提供大脑解剖结构、功能及代谢等多方面的信息. 近年来，随着人们对糖尿病脑病关注度的不断增加和认识的不断加深，磁共振成像和活体波谱开始并越来越多地被应用于该疾病的研究. 该文综述磁共振成像与活体波谱技术在糖尿病脑病研究中的应用及最新进展.

关键词: 磁共振成像(MRI), 磁共振波谱(MRS), 糖尿病脑病, 糖尿病纹状体病变

Abstract:

Diabetes mellitus (DM) is a chronic metabolic disease characterized by either insulin deficiency or insulin resistance. It is known that longstanding DM causes damages to the central nervous system. The manifestations include brain atrophy and white matter lesions. Magnetic resonance imaging (MRI) and spectroscopy (MRS) are noninvasive and can provide information on the anatomical, functional and metabolic aspects of the brain. MRI and MRS have been used as diagnostic tools for many brain diseases, including diabetic encephalopathy. In this review, clinical manifestations of diabetic encephalopathy were reviewed, with emphasis on the findings detected by MRI/MRS techniques.

Key words: MRI, MRS, diabetic encephalopathy, diabetic striatopathy

中图分类号:

O482.53

黄明明, 林富春, 高丽凤, 雷皓. 糖尿病脑病的磁共振研究[J]. 波谱学杂志, 2012, 29(3): 446-456.

HUANG Ming-Ming, LIN Fu-Chun, GAO Li-Feng, LEI Hao. Diabetic Encephalopathy Studied by Magnetic Resonance Imaging and Spectroscopy[J]. Chinese Journal of Magnetic Resonance, 2012, 29(3): 446-456.

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