磁共振结构成像在自闭症研究中的应用

摘要/Abstract

摘要：

自闭症，又称作孤独症，是一种常发生在儿童中的广泛性发育障碍，表现为交流障碍、语言障碍以及重复刻板的行为和狭窄的兴趣爱好. 磁共振成像作为一种无损伤的和多参数的影像方法，其各种检测手段均被应用于自闭症实验研究，其中结构磁共振成像(sMRI)和功能磁共振成像(fMRI)研究居多. 研究表明自闭症患者脑部结构发生了显著性改变. 该文综述了当前世界上利用磁共振结构成像研究自闭症的主要成果，包括结构磁共振成像研究脑体积变化，扩散张量成像研究自闭症的脑白质损伤. 该文也说明磁共振成像是一种十分有用的研究工具，有望在将来更多被用于探索自闭症的未知领域.

关键词: 磁共振成像(MRI), 脑结构, 自闭症

Abstract:

Autism is now widely viewed as a neurodevelopmental disorder. Structural magnetic resonance imaging (MRI) techniques, including voxelbased morphormetry and diffusion tensor imaging, have been applied to study autism. In this paper, the recent literature in this area was reviewed. It was showed that structural MRI is a powerful technique that holds great promise to understand the pathology of autism.

Key words: MRI, brain structure, autism

中图分类号:

O482.53

杜小霞, 王慧, 沈国华, 李鲠颖. 磁共振结构成像在自闭症研究中的应用[J]. 波谱学杂志, 2012, 29(3): 457-564.

DU Xiao-Xia, WANG Hui, SHEN Guo-Hua, LI Geng-Ying. Structural Magnetic Resonance Imaging Findings in Autism[J]. Chinese Journal of Magnetic Resonance, 2012, 29(3): 457-564.

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