T2/FLAIR错配征的定量参数在评价较低级别胶质瘤分子分型的诊断价值

doi:10.11938/cjmr20212899

波谱学杂志 ›› 2022, Vol. 39 ›› Issue (1): 56-63.doi: 10.11938/cjmr20212899

T₂/FLAIR错配征的定量参数在评价较低级别胶质瘤分子分型的诊断价值

王瀚苇^1,²,吴昊^1,²,田静^1,²,张俊峰^1,²,钟鹏³,陈立朝⁴,王舒楠^1,^2,*()

1. 陆军军医大学大坪医院放射科, 重庆 400042
2. 重庆市影像学与核医学临床研究中心, 重庆 400042
3. 陆军军医大学大坪医院病理科, 重庆 400042
4. 陆军军医大学大坪医院神经外科, 重庆 400042

收稿日期:2021-03-23 出版日期:2022-03-05 发布日期:2021-06-29
通讯作者: 王舒楠 E-mail:wangshunan@tmmu.edu.cn
基金资助:
国家自然科学基金青年科学基金资助项目(81701661)

The Diagnostic Value of Quantitative Parameters of T₂/FLAIR Mismatch Sign in Evaluating the Molecular Typing of Lower-grade Gliomas

Han-wei WANG^1,²,Hao WU^1,²,Jing TIAN^1,²,Jun-feng ZHANG^1,²,Peng ZHONG³,Li-zhao CHEN⁴,Shu-nan WANG^1,^2,*()

1. Department of Radiology, Daping Hospital, Army Medical University, Chongqing 400042, China
2. Chongqing Clinical Research Centre of Imaging and Nuclear Medicine, Chongqing 400042, China
3. Department of Pathology, Daping Hospital, Army Medical University, Chongqing 400042, China
4. Department of Neurosurgery, Daping Hospital, Army Medical University, Chongqing 400042, China

Received:2021-03-23 Online:2022-03-05 Published:2021-06-29
Contact: Shu-nan WANG E-mail:wangshunan@tmmu.edu.cn

摘要/Abstract

摘要：

本文回顾性分析19例经病理证实为WHO Ⅱ-Ⅲ级且具有T₂/FLAIR错配征的脑胶质瘤患者.从患者的影像数据中提取肿瘤区整体特征和错配区影像参数进行定量分析，探讨T₂/FLAIR错配征在评价异柠檬酸脱氢酶（IDH）突变伴1p/19q未联合缺失型（IDH^MUT/1p/19q⁺）较低级别胶质瘤（LGG）的诊断效能.本研究表明，整体及部分T₂/FLAIR错配征可作为预测IDH^MUT/1p/19q⁺ LGG的影像标志物.肿瘤区整体影像特征联合错配区定量参数有助于提高对IDH^MUT/1p/19q⁺ LGG的诊断效能.

关键词: 磁共振成像（MRI）, T₂/FLAIR错配征, 分子分型, 较低级别胶质瘤, 定量参数

Abstract:

This paper performed a retrospective analysis of 19 patients diagnosed with pathologically-verified WHO Ⅱ-Ⅲ grade glioma with T₂/FLAIR mismatch sign. We extracted the overall characteristics of the tumor area and the image parameters of the mismatch regions from the patients' imaging data for quantitative analysis. Afterward, we investigated how T₂/FLAIR mismatch sign affected the diagnostic efficacy for isocitrate dehydrogenase (IDH)-mutant and 1p/19q non-codeleted (IDH^MUT/1p/19q⁺) lower-grade gliomas (LGG). This study showed that the overall and partial T₂/FLAIR mismatch sign can be used as an imaging marker to predict IDH^MUT/1p/19q⁺ LGG. The overall imaging characteristics of the tumor area combined with the quantitative parameters of the mismatch regions can improve the diagnostic efficacy for IDH^MUT/1p/19q⁺ LGG.

Key words: magnetic resonance imaging (MRI), T₂/FLAIR mismatch sign, molecular typing, lower-grade gliomas, quantitative parameters

中图分类号:

O482.53

王瀚苇,吴昊,田静,张俊峰,钟鹏,陈立朝,王舒楠. T₂/FLAIR错配征的定量参数在评价较低级别胶质瘤分子分型的诊断价值[J]. 波谱学杂志, 2022, 39(1): 56-63.

Han-wei WANG,Hao WU,Jing TIAN,Jun-feng ZHANG,Peng ZHONG,Li-zhao CHEN,Shu-nan WANG. The Diagnostic Value of Quantitative Parameters of T₂/FLAIR Mismatch Sign in Evaluating the Molecular Typing of Lower-grade Gliomas[J]. Chinese Journal of Magnetic Resonance, 2022, 39(1): 56-63.

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参考文献 18

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	阳性组（n=9）	假阳性组（n=10）	p值
男性/女性	7/2	6/4	0.628
年龄/岁	35.00±10.55	46.40±13.34	0.056
WHO Ⅱ级	8	7	0.582
WHO Ⅲ级	1	3	0.582

		阳性组（n=9）	假阳性组（n=10）	p值
瘤周水肿	有	5 (55.6%)	10 (100%)	0.033
瘤周水肿	无	4 (44.4%)	0	0.033
肿瘤边缘	清楚	6 (66.7%)	3 (30%)	0.179
肿瘤边缘	模糊	3 (33.3%)	7 (70%)	0.179
强化	有	1 (11.1%)	5 (50%)	0.141
强化	无	8 (88.9%)	5 (50%)	0.141

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T₂/FLAIR错配征的定量参数在评价较低级别胶质瘤分子分型的诊断价值

The Diagnostic Value of Quantitative Parameters of T₂/FLAIR Mismatch Sign in Evaluating the Molecular Typing of Lower-grade Gliomas

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