结合局部一致性和低频振幅探究躯体症状障碍患者大脑自发性活动的改变

doi:10.11938/cjmr20212894

波谱学杂志 ›› 2022, Vol. 39 ›› Issue (1): 64-71.doi: 10.11938/cjmr20212894

结合局部一致性和低频振幅探究躯体症状障碍患者大脑自发性活动的改变

崔阳阳^1,³,梁怀彬²,朱千³,汤伟³,高婷婷³,刘建仁^2,*(),杜小霞^1,*()

1. 上海体育学院心理学院, 上海 200438
2. 上海交通大学医学院附属第九人民医院神经内科, 上海 200011
3. 华东师范大学物理与电子科学学院物理系, 上海市磁共振重点实验室, 上海 200062

收稿日期:2021-03-01 出版日期:2022-03-05 发布日期:2021-06-02
通讯作者: 刘建仁,杜小霞 E-mail:liujr021@vip.163.com;duxiaoxia@sus.edu.cn
基金资助:
国家自然科学基金资助项目(81571658)

A Study on the Alteration of Spontaneous Brain Activity in Somatic Symptoms Disorder Combining Regional Homogeneity and Amplitude of Low-frequency Fluctuation

Yang-yang CUI^1,³,Huai-bin LIANG²,Qian ZHU³,Wei TANG³,Ting-ting GAO³,Jian-ren LIU^2,*(),Xiao-xia DU^1,*()

1. Department of Psychology, Shanghai University of Sport, Shanghai 200438, China
2. Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
3. Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China

Received:2021-03-01 Online:2022-03-05 Published:2021-06-02
Contact: Jian-ren LIU,Xiao-xia DU E-mail:liujr021@vip.163.com;duxiaoxia@sus.edu.cn

摘要/Abstract

摘要：

躯体症状障碍（somatic symptom disorder，SSD）是一种常见的医学疾病，致病原因涉及生物学、心理学及社会因素.目前关于SSD的神经机制知之甚少.本研究通过静息态功能磁共振成像（functional magnetic resonance imaging，fMRI），结合低频振幅（amplitudes of low-frequency fluctuation，ALFF）和局部一致性（regional homogeneity，ReHo）分析探究45位SSD患者和43位健康对照自发性脑活动特征的区别.结果发现：与对照组相比，SSD患者右侧扣带回中部的ReHo值显著升高，而右侧楔前叶、左侧颞下回延伸到左侧颞中回和左侧海马旁回、右侧脑桥的ReHo值显著降低.同时，SSD患者扣带回中部延伸至左侧额中回、右侧脑岛延伸至右侧额下回、左侧额中回延伸至左侧前扣带回的ALFF值均显著升高.这些脑区的脑功能与自我加工、情绪处理、身体知觉等有关，与SSD发病机制有重要联系.

关键词: 躯体症状障碍（SSD）, 局部一致性, 低频振幅（ALFF）, 功能磁共振成像（fMRI）

Abstract:

Somatic symptom disorder (SSD) is a common medical disorder characterized by various biological, psychological, and social pathogenic factors. At present, little is known about the neural mechanism of SSD. This study evaluated the dysfunction in 45 patients with SSD and 43 controls by combining the amplitudes of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) methods with resting-state functional magnetic resonance imaging (fMRI). The patients with SSD exhibited significantly greater ReHo values in the right middle cingulate gyrus, and smaller ReHo values in the right precuneus, the left inferior temporal gyrus extending to the left middle temporal gyrus and the left parahippocampal gyrus, and the right pons compared with the controls. The SSD patients showed higher ALFF values in the middle cingulate gyrus extending to the left middle frontal gyrus, the right insula extending to the right inferior frontal gyrus, and left middle frontal gyrus extending to the left anterior cingulate cortex. These dysfunction areas are involved in self-relevant processes, emotional processing, and body perception, which are closely related to the pathogenesis of SSD.

Key words: somatic symptom disorder (SSD), regional homogeneity, amplitudes of low-frequency fluctuation (ALFF), functional magnetic resonance imaging (fMRI)

中图分类号:

O482.53

崔阳阳,梁怀彬,朱千,汤伟,高婷婷,刘建仁,杜小霞. 结合局部一致性和低频振幅探究躯体症状障碍患者大脑自发性活动的改变[J]. 波谱学杂志, 2022, 39(1): 64-71.

Yang-yang CUI,Huai-bin LIANG,Qian ZHU,Wei TANG,Ting-ting GAO,Jian-ren LIU,Xiao-xia DU. A Study on the Alteration of Spontaneous Brain Activity in Somatic Symptoms Disorder Combining Regional Homogeneity and Amplitude of Low-frequency Fluctuation[J]. Chinese Journal of Magnetic Resonance, 2022, 39(1): 64-71.

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	SSD患者	健康对照	p值
男性/女性	20/25	19/24	0.97
年龄/岁	50.74±13.65	52.07±11.48	0.88
病程/年	2.03±0.85	/
PHQ-9	8.16±5.17	0~4
GAD-7	7.48±5.50	0~4
HAMA	9.31±4.62	0~8
HAMD	8.20±5.27	0~8
MMSE	27.39±2.35	27~30

	脑区	团块大小	T值	MNI坐标			p值^a
	脑区	团块大小	T值	x	y	z	p值^a
SSD患者 > 健康对照组	右侧扣带回中部	104	4.59	9	9	42	0.001
SSD患者 < 健康对照组	右侧楔前叶	83	5.04	18	?60	33	0.005
	左侧颞下回延伸至左侧颞中回及海马旁回	57	4.37	?33	0	?42	0.002
	右侧脑桥	52	4.24	21	?33	?36	0.003

	显著脑区	团块大小	T值	MNI坐标			p值^a
	显著脑区	团块大小	T值	x	y	z	p值^a
SSD患者 > 健康对照组	扣带回中部延伸到左侧额中回	63	4.93	?3	9	42	0.006
	右侧脑岛延伸至右侧额下回	52	4.78	36	15	9	0.016
	左侧额中回延伸至左侧前扣带回	44	4.74	?3	42	18	0.034

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结合局部一致性和低频振幅探究躯体症状障碍患者大脑自发性活动的改变

A Study on the Alteration of Spontaneous Brain Activity in Somatic Symptoms Disorder Combining Regional Homogeneity and Amplitude of Low-frequency Fluctuation

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