波谱学杂志 ›› 2014, Vol. 31 ›› Issue (4): 596-607.doi: 10.11938/cjmr20140414

• 综述评论 • 上一篇    下一篇

流感病毒融合肽磁共振研究进展

杜天鹏1,2,张子微1,曾丹云1,刘买利1,姜 凌1*   

  1. 1. 波谱与原子分子物理国家重点实验室,武汉磁共振中心(中国科学院 武汉物理与数学研究所),湖北 武汉 430071;
    2. 中国科学院大学,北京100049
  • 收稿日期:2014-01-17 修回日期:2014-10-28 出版日期:2014-12-05 发布日期:2014-12-05
  • 通讯作者: 姜凌 E-mail:lingjiang@wipm.ac.cn
  • 作者简介:杜天鹏(1984-),男,河南信阳人,博士研究生,分析化学专业. *通讯联系人:姜凌,电话:027-87198493,E-mail:lingjiang@wipm.ac.cn.
  • 基金资助:

    国家自然科学基金资助项目(21173257).

Structure and Function of Influenza Virus Fusion Peptide Studied by Nuclear Magnetic Resonance Spectroscopy

DU Tian-peng1,2,ZHANG Zi-wei1,ZENG Dan-yun1,LIU Mai-li1,JIANG Ling1*   

  1. 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;
    2. University of Chinese Academy of Science, Beijing 100049, China
  • Received:2014-01-17 Revised:2014-10-28 Online:2014-12-05 Published:2014-12-05
  • About author:*Corresponding author:JIANG Ling, Tel: 027-87198493, E-mail: lingjiang@wipm.ac.cn.
  • Supported by:

    国家自然科学基金资助项目(21173257).

摘要:

流感病毒融合肽在流感病毒感染宿主细胞的过程中扮演关键角色,解析其三维结构是了解病毒融合机制的关键.融合肽结构的研究历经十几年,期间提出了多种融合模型和假说,至今仍然是科学家们感兴趣的热点问题.核磁共振方法是研究融合肽结构的主要手段之一,该文综述了该领域近几年的重要进展,以期对流感病毒融合肽的融合机制有更深入的认识.

关键词: 液体核磁共振, 流感病毒融合肽, 三维结构, 融合机制

Abstract:

The influenza fusion peptide plays a pivotal role in the fusion process of the viral membrane with the host-cell endosomal membrane. Recent success of solving the structure of influenza hemagglutinin fusion peptide has led to a new understanding of the fusion mechanism. Although a few hypotheses have been proposed, it is still of great interest to investigate the structure-function relationship of the fusion peptide. In this paper, the progresses in the field for the last decade is reviewed.

Key words: NMR, influenza fusion peptide, 3D structure, mechanism of fusion process

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