波谱学杂志 ›› 2006, Vol. 23 ›› Issue (4): 457-465.

• 研究论文 • 上一篇    下一篇

几种含氮化合物的核磁共振测试

欧阳捷1; 张巍1; 彭捷1; 邓志威1*; 李丽娅2; 林文翰2*   

  1. (1.北京师范大学 分析测试中心,北京 100875;2.北京大学 天然药物及仿生药物国家重点实验室,北京 100083)
  • 收稿日期:2006-02-09 修回日期:2006-05-25 出版日期:2006-12-05 发布日期:2009-12-05
  • 通讯作者: 邓志威

NMR Analysis of Nitrogen Containing Compounds

OUYANG Jie1; ZHANG Wei1; PENG Jie1; DENG Zhi-wei1*; LI Li-ya2; LIN Wen-han2*
  

  1. (1.Analytical & Testing Center, Beijing Normal University, Beijing 100875, China; 2.State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China)
  • Received:2006-02-09 Revised:2006-05-25 Online:2006-12-05 Published:2009-12-05
  • Contact: Deng Zhi-wei

摘要: 结合曲氨南(Aztreonam)、奥美拉唑(Omeprazole)与一种席夫碱对含氮化合物在核磁共振(NMR)测试中的某些特性进行了研究. 结果表明,14N四偶极矩、分子间氢键以及分子间质子转移导致的异构,是影响含氮化合物核磁特性的主要因素. 这些因素虽然在NMR的实验设计与谱图分析方面是无法避免的,但却能为结构解析以及其他化学研究方面提供一定的有趣的信息.

关键词: 核磁共振, 含氮化合物, 分子间氢键, 异构, 14N四偶极矩

Abstract: In this work, the NMR characteristics of several nitrogen containing compounds, including Aztreonam, Omeprazole and a Schiff base, were investigated. The results show that quadrupole moment of 14N nuclei[1], inter-molecular hydrogen bonding and tautomic equilibria of intra-molecular proton transformation are the major factors influencing the NMR characteristics of these compounds. Based on the results, it is suggested that the aforementioned factors should be considered when designing NMR experiments for and analyzing NMR spectra of nitrogen containing compounds, since knowing the influences of these factors may help gaining more information on the structural and chemical properties of the compounds.

Key words: NMR, nitrogen containing compounds, inter-molecular hydrogen bonding, tautomerism equilibria, quadrupole moment

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