滇黄精中两个呋甾皂苷的NMR研究

波谱学杂志 ›› 2006, Vol. 23 ›› Issue (1): 31-40.

滇黄精中两个呋甾皂苷的NMR研究

1.军事医学科学院放射与辐射医学研究所, 北京 100850; 2.河南中医学院, 河南郑州 450008

收稿日期:2005-07-04 修回日期:2005-09-19 出版日期:2006-03-05 发布日期:2006-03-05
基金资助:
This work is supported by Science and Technology Developmental Foundation of Henan Province (0422030700).

NMR Studies of Two Furostanol Saponins Isolated from Polygonatum Kingianum

1.Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China;
2.Henan Collage of Traditional Chinese Medicine, Zhengzhou 450008, China

Received:2005-07-04 Revised:2005-09-19 Online:2006-03-05 Published:2006-03-05

摘要/Abstract

摘要：

从滇黄精新鲜根茎中分离得到一对立体异构的呋甾皂苷, 利用1D、2D NMR鉴定其结构为: 26-O-β-D-吡喃葡萄糖基25(S)-呋甾-△^5（6）-烯-3β, 22, 26-三羟基-12酮基-3-O-β-D-吡喃葡萄糖基(1→4)-β-D-吡喃呋糖苷(1, 25S-kingianoside D)和26-O-β-D-吡喃葡萄糖基25(R)-呋甾-△^5（6）-烯-3β-, 22, 26-三羟基-12酮基-3-O-β-D-吡喃葡萄糖基(1→4)-β-D-吡喃呋糖苷(2, kingianoside D). 利用1D、2D NMR对两个呋甾皂苷25位的立体构型进行了确定, 并对其碳、氢信号进行了全归属. 

关键词: 核磁共振, 呋甾皂苷, 滇黄精

Abstract:

A pair of stereoisomeric furostanol saponins were isolated from fresh rhizomes of Polygonatum kingianum, and identified as 26-O-β-D-glucopyranosyl 25(S)-furostane-5-en-3β, 22, 26-triol-12-on-3-O-β-D-glucopyranosyl (1→4)-β-D-fucopyranoside (1) and 26-O-β-D-glucopyranosyl 25(R)-furostane-5-en-3β, 22, 26-triol-12-on-3-O-β-D-glucopyranosyl (1→4)-β-D- fucopyranoside (2), respectively, by 1D ¹H and ¹³C NMR and 2D NMR (including ¹H-¹H COSY, HSQC and HMBC). ¹H and ¹³C chemical shifts of the two compounds were completely assigned, and the configurations of the methyl group at C-25 were determined.

Key words: NMR, furostanol saponin, Polygonatum kingianum

中图分类号:

O641

张洁, 马百平, 康利平, 余河水, 杨云, 颜贤忠. 滇黄精中两个呋甾皂苷的NMR研究[J]. 波谱学杂志, 2006, 23(1): 31-40.

ZHANG Jie, MA Bai-Ping, KANG Li-Ping, YU He-Shui, YANG Yun, YA Xian-Zhong. NMR Studies of Two Furostanol Saponins Isolated from Polygonatum Kingianum[J]. Chinese Journal of Magnetic Resonance, 2006, 23(1): 31-40.

参考文献

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