波谱学杂志 ›› 2004, Vol. 21 ›› Issue (3): 365-369.

• 研究简报 • 上一篇    下一篇

苯基哌嗪衍生物的NMR波谱研究

肖志会1,袁牧2,黄建设1,吴军1   

  1. 1.中国科学院南海海洋研究所,广东省海洋药物重点实验室,广东 广州  510301; 
    2.中国科学院天然产物化学重点实验室, 贵州 贵阳  550002
  • 收稿日期:2004-02-19 修回日期:2004-04-05 出版日期:2004-09-05 发布日期:2004-09-05
  • 基金资助:

    国家自然科学基金资助项目(30060087).

A NMR STUDY OF PHENYLPIPERAZINE DERIVATIVES

 XIAO Zhi-Hui1, YUAN Mu2, HUANG Jian-She1, WU Jun1   

  1. 1.Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301,China; 2.The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002,China
  • Received:2004-02-19 Revised:2004-04-05 Online:2004-09-05 Published:2004-09-05
  • Supported by:

    国家自然科学基金资助项目(30060087).

摘要:

通过1H NMR、13C NMR、及HMBC、HSQC、1H-1H DQFCOSY等2D NMR方法对新合成的10个苯基哌嗪衍生物类抗高血压药物进行结构鉴定, 并对这些化合物的1H NMR和13C NMR信号进行了全归属. 初步探讨了取代基对分子13C化学位移的影响. 

关键词: 核磁共振, 归属, 化学位移, 苯基哌嗪

Abstract:

Having the potential of being used as α1-adrenoceptor antagonist and new antihypertensive drugs, ten phenylpiperazine derivatives were synthesized, and their structures were determined by 1H NMR, 13C NMR, HMBC, HSQC and 1H-1H DQF-COSY. The 1H and 13C chemical shifts of these compounds were assigned. The relationship between the substitute groups and the 13C chemical shifts was discussed.

Key words: NMR, assignments, chemical shift, phenylpiperazine

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