核磁共振技术在生物组织中的应用

摘要/Abstract

摘要：

在生物组织内部存在大量的生化、生理反应以及分子的扩散运动，它们相互独立, 又相互关联，共同构成一个生化反应网络. 在病理条件下，某些生化反应过程会发生改变，代谢中间体可能会出现质和量的变化. 核磁共振 (NMR)可以对这些过程的研究提供非常有用的信息. 目前，有3种核磁共振波谱技术可以用于生物组织的研究：① 活体组织定域波谱技术；② 生物组织提取物的液体高分辨核磁共振技术；③ 离体组织的高分辨魔角旋转技术. 这些方法各有优劣，互为补充. 介绍了在生物组织的NMR研究方面的最新进展.

关键词: 核磁共振(NMR), 活体磁共振波谱(MRS), 液体高分辨核磁共振(HR NMR), 高分辨魔角旋转(HR-MAS NMR), 生物组织

Abstract:

There are a great number of physiological and biochemical reactions inside biological tissues, which are either independent or correlated to each other. Useful information can be obtained by Nuclear Magnetic Resonance (NMR) technique in studying the metabolic processes. There are presently three kinds of NMR techniques for studying biological tissues: ① in vivo Magnetic Resonance Spectroscopy (MRS); ② High-Resolution in vitro Nuclear Magnetic Resonance (HR-NMR); ③ High-Resolution in vitro Magic Angle Spinning Nuclear Magnetic Resonance (HR-MAS NMR), each has its own advantages and disadvantages and are complementary to each other. In this article, progresses in the NMR studies of biological tissues are reviewed.

Key words: nuclear magnetic resonance (NMR), magnetic resonance spectroscopy in vivo (MRS), high-resolution magnetic resonance spectroscopy in vitro (HR-NMR), high-resolution magic angle spinning magnetic resonance spectroscopy in vitro (HR-MAS NMR), biological tissues

中图分类号:

O482.53

陈文学, 邓风, 岳勇. 核磁共振技术在生物组织中的应用[J]. 波谱学杂志, 2004, 21(1): 127-139.

CHEN Wen-Xue, DENG Feng, YUE Yong. APPLICATIONS OF NMR TECHNIQUES TO BIOLOGICAL TISSUES[J]. Chinese Journal of Magnetic Resonance, 2004, 21(1): 127-139.

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