波谱学杂志 ›› 2019, Vol. 36 ›› Issue (1): 113-126.doi: 10.11938/cjmr20182655

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天然C19-二萜生物碱的研究进展及其核磁共振波谱特征

尹田鹏1,2, 罗智慧1, 蔡乐2, 丁中涛2   

  1. 1. 遵义医科大学珠海校区, 珠海市中药基础及应用研究重点实验室, 广东 珠海 519041;
    2. 云南大学 化学科学与工程学院, 云南省高校功能分子分析与生物转化重点实验室, 云南 昆明 650091
  • 收稿日期:2018-05-23 出版日期:2019-03-05 发布日期:2018-06-21
  • 通讯作者: 丁中涛,Tel:0871-65032667,E-mail:ztding@ynu.edu.cn E-mail:ztding@ynu.edu.cn
  • 基金资助:
    国家自然科学基金(31860095);贵州省科学技术基金(黔科合基础[2018]1193);云南省高校功能分子分析与生物转化重点实验开放基金.

Research Progress and NMR Spectral Features of Natural C19-Diterpenoid Alkaloids

YIN Tian-peng1,2, LUO Zhi-hui1, CAI Le2, DING Zhong-tao2   

  1. 1. Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, China;
    2. Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
  • Received:2018-05-23 Online:2019-03-05 Published:2018-06-21

摘要: C19-二萜生物碱是二萜生物碱中数量最多的一类,主要分布于毛茛科的乌头属、翠雀属和飞燕草属植物中.C19-二萜生物碱结构复杂、生理活性显著,一直吸引着科研工作者的广泛关注.本文主要对2010~2018年报道的天然来源C19-二萜生物碱的研究进行总结,并归纳了C19-二萜生物碱各子类型的核磁共振(NMR)结构特征和解析方式,以期为C19-二萜生物碱的深入研究及开发提供参考依据.

关键词: C19-二萜生物碱, 核磁共振(NMR)波谱, 结构解析, 乌头属, 翠雀属

Abstract: Majority of diterpenoid alkaloids are C19-diterpenoid alkaloids found in the plants from the genera Aconitum, Delphinium and Consolida (Ranunculaceae). C19-diterpenoid alkaloids have attached lots of research interests due to their complex structures and remarkable pharmacological activities. This paper reviewed the structural features of natural C19-diterpenoid alkaloids reported in literature from 2010 to 2018, focusing on the NMR spectral characteristics of different subtypes of C19-diterpenoid alkaloids and how their structures could be elucidated from the NMR data. The work may provide a reference for the further research and development of C19-diterpenoid alkaloids.

Key words: C19-diterpenoid alkaloids, nuclear magnetic resonance (NMR)spectroscopy, structural elucidation, Aconitum, Delphinium

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