一种带外部锁场通道的小型化核磁共振射频探头设计

doi:10.11938/cjmr20223044

波谱学杂志 ›› 2023, Vol. 40 ›› Issue (3): 332-340.doi: 10.11938/cjmr20223044

一种带外部锁场通道的小型化核磁共振射频探头设计

王峰^1,²,刘庭伟^1,²,徐雅洁^2,^*(),郁朋^2,³,王亚²,彭博文^2,⁴,杨晓冬^2,^#()

1.长春理工大学电子信息工程学院，吉林长春 130022
2.中国科学院苏州生物医学工程技术研究所，江苏苏州 215163
3.济南国科医工科技发展有限公司，山东济南 250013
4.中国科学技术大学，安徽合肥 230026

收稿日期:2022-12-16 出版日期:2023-09-05 在线发表日期:2023-02-28
通讯作者: #Tel: 18900616030, E-mail: xiaodong.yang@sibet.ac.cn;*Tel: 15250434900, E-mail: xuyj@sibet.ac.cn.
基金资助:
中国科学院磁共振技术联盟项目(E0290301);山东省自然科学基金青年项目(ZR2021QA091)

A Miniaturised NMR RF Probe Design with External Field-locking Channel

WANG Feng^1,²,LIU Tingwei^1,²,XU Yajie^2,^*(),YU Peng^2,³,WANG Ya²,PENG Bowen^2,⁴,YANG Xiaodong^2,^#()

1. School of Electronic and Information Engineering, Changchun University of Science and Technology, Changchun 130022, China
2. Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China
3. Jinan Guoke Medical Technology Development Co., Ltd., Jinan 250013, China
4. University of Science and Technology of China, Hefei 230026, China

Received:2022-12-16 Published:2023-09-05 Online:2023-02-28
Contact: #Tel: 18900616030, E-mail: xiaodong.yang@sibet.ac.cn;*Tel: 15250434900, E-mail: xuyj@sibet.ac.cn.

摘要/Abstract

摘要：

温度漂移是影响桌面式核磁共振波谱仪测量精度的一个重要因素，在探头中添加锁场线圈实现场频联锁是抑制温度漂移的常用手段．本文基于实验室紧凑型Halbach磁体，设计了一套带有外部锁场功能的双通道探头．针对目标区域，使用COMSOL仿真对比了螺线管线圈、鞍形线圈和亥姆霍兹线圈的磁场均匀性、信噪比和品质因数，发现螺线管线圈具有最佳综合性能．进一步针对螺线管线圈结构，对线圈直径、高度、匝数、匝间距以及漆包线半径进行了仿真优化，得到漆包线半径为0.4 mm、线圈直径和高度为8.2 mm、匝间距为1.6 mm、匝数为5是最优螺线管尺寸．基于仿真结果，制作了探头实物，并配合外围电路进行测试．结果表明，两个线圈通道之间串扰较小，信号检测通道信噪比达到50以上，锁场通道信噪比达到20以上．锁场实验结果表明，添加锁场后整体系统的频率漂移约为0.2 ppm/h（1 ppm=10^-6），验证了此探头设计可用于基于紧凑型Halbach磁体的磁共振设备．

关键词: 核磁共振（NMR）, 线圈优化, 双通道探头, 锁场

Abstract:

Temperature drift is an important factor affecting the measurement accuracy of desktop NMR spectrometers, and adding a field-locking coil to the probe to achieve field-frequency interlocking is a common means of suppressing temperature drift. In this paper, a dual-channel miniaturised RF probe with an external field-locking channel is designed based on a laboratory compact Halbach magnet. The coil diameter, height, number of turns, turn spacing and enamelled wire radius were optimized based on the solenoid structure. The optimum solenoid size was obtained with an enameled wire radius of 0.4 mm, a coil diameter and height of 8.2 mm, a turn spacing of 1.6 mm and a number of turns of 5. Based on the simulation results, the detection and field-locking coils were fabricated, and tested in conjunction with the peripheral circuitry. The results show that the crosstalk between the two coils is low, the signal-to-noise ratio of the detection channel is above 50 and the signal-to-noise ratio of the locking channel is above 20. Final field locking experiments were performed and the frequency drift of the overall system after equipping the locking field was approximately 0.2 ppm/h (1 ppm=10^-6), verifying that this probe design can be applied in compact Halbach magnet-based NMR analysis facilities.

Key words: nuclear magnetic resonance (NMR), coil optimization, dual-channel probe, locked field

中图分类号:

O482.53

王峰, 刘庭伟, 徐雅洁, 郁朋, 王亚, 彭博文, 杨晓冬. 一种带外部锁场通道的小型化核磁共振射频探头设计[J]. 波谱学杂志, 2023, 40(3): 332-340.

WANG Feng, LIU Tingwei, XU Yajie, YU Peng, WANG Ya, PENG Bowen, YANG Xiaodong. A Miniaturised NMR RF Probe Design with External Field-locking Channel[J]. Chinese Journal of Magnetic Resonance, 2023, 40(3): 332-340.

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参考文献 21

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	鞍型	亥姆霍兹	螺线管
B₁场不均匀度（δ）	49.49%	8.2%	23.89%
相对信噪比（SNR）	3.6×10^-4	5.43×10^-4	1.03×10^-3
品质因数（Q）	87.11	95.41	210.89

漆包线半径r/mm	相对信噪比SNR	品质因数Q	B₁场不均匀度δ	综合性能M
0.10	1.61×10^-3	132.69	25.95%	0.79
0.15	1.56×10^-3	126.54	26.76%	0.51
0.20	1.55×10^-3	130.86	25.77%	0.63
0.25	1.52×10^-3	130.66	25.21%	0.61
0.30	1.53×10^-3	144.09	24.38%	0.96
0.35	1.51×10^-3	148.15	23.91%	1.06
0.40	1.48×10^-3	146.73	23.07%	1.10
0.45	1.47×10^-3	163.60	25.28%	0.87
0.50	1.45×10^-3	161.85	24.26%	0.89

一种带外部锁场通道的小型化核磁共振射频探头设计

A Miniaturised NMR RF Probe Design with External Field-locking Channel

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