超导磁共振仪器设备国产化现状及挑战

doi:10.11938/cjmr20212961

摘要/Abstract

摘要：

磁共振在化学分析和医学影像等领域发挥着不可或缺的作用，而磁共振仪器设备是开展磁共振研究的必要前提.长期以来，国外仪器厂商在我国磁共振仪器市场居于垄断地位.近年来，随着我国在磁共振仪器研发和产业化方面不断取得进展，市场份额为外商垄断的局面已大为改观.本文调研综述了我国磁共振仪器设备研制的现状，以及面临的若干挑战.

关键词: 磁共振, 仪器设备, 国产化, 现状

Abstract:

Magnetic resonance (MR) plays an essential role in chemical analysis and medical imaging. The reliable MR instrument is a prerequisite for MR related research. Foreign instrument companies have monopolized the MR instrument supply in China for a long time. Recently, the situation has witnessed impressive improvement due to progress made by Chinese domestic companies and institutions in developing and manufacturing MR instruments. This paper surveyed and reviewed the status and challenges of the domestic manufacturing of MR instruments in China.

Key words: magnetic resonance (MR), instrument, domestic manufacturing, status

中图分类号:

O482.53

刘莲花,蒋滨,陈代谢,苏驰. 超导磁共振仪器设备国产化现状及挑战[J]. 波谱学杂志, 2022, 39(3): 345-355.

Lian-hua LIU,Bin JIANG,Dai-xie CHEN,Chi SU. The Status and Challenge of the Domestic Manufacturing of Superconduct Magnetic Resonance Instruments in China[J]. Chinese Journal of Magnetic Resonance, 2022, 39(3): 345-355.

参考文献 38

1	PAULI W . Zur frage der theoretischen deutung der satelliten einiger spektrallinien und ihrer beeinflussung durch magnetische Felder[J]. Naturwissenschaften, 1924, 12 (37): 741- 743. doi: 10.1007/BF01504828
2	KELLOG J M B , RABI I I , RAMSEY N F , et al. The magnetic moments of the proton and the deuteron - The radiofrequency spectrum of H-2 in various magnetic fields[J]. Phys Rev, 1939, 56 (8): 728- 743. doi: 10.1103/PhysRev.56.728
3	BLOCH F . Nuclear induction[J]. Phys Rev, 1946, 70 (7, 8): 460- 474.
4	PURCELL E M , TORREY H C , POUND R V . Resonance absorption by nuclear magnetic moments in a solid[J]. Phys Rev, 1946, 69 (1, 2): 37- 38.
5	PROCTOR W G , YU F C . The dependence of a nuclear magnetic resonance frequency upon chemical compound[J]. Phys Rev, 1950, 77 (5): 717.
6	ARNOLD J T , DHARMATTI S S , PACKARD M E . Chemical effects on nuclear induction signals from organic compounds[J]. J Chem Phys, 1951, 19 (4): 507. doi: 10.1063/1.1748264
7	GUTOWSKY H S , MCCALL D W . Nuclear magnetic resonance fine structure in liquids[J]. Phys Rev, 1951, 82 (5): 748- 749. doi: 10.1103/PhysRev.82.748
8	SHOOLERY J N , ROGERS M T . Nuclear magnetic resonance spectra of steroids[J]. J Am Chem Soc, 1958, 80 (19): 5121- 5135. doi: 10.1021/ja01552a031
9	LAUTERBUR P C . C-13 nuclear magnetic resonance spectra[J]. J Chem Phys, 1957, 26 (1): 217- 218. doi: 10.1063/1.1743253
10	ERNST R R , ANDERSON W A . Application of Fourier transform spectroscopy to magnetic resonance[J]. Rev Sci Instrum, 1966, 37 (1): 93. doi: 10.1063/1.1719961
11	AUE W P , BARTHOLDI E , ERNST R R . Two-dimensional spectroscopy. Application to nuclear magnetic resonance[[J]. J Chem Phys, 1976, 64 (5): 2229- 2246. doi: 10.1063/1.432450
12	SAUNDERS M , WISHNIA A , KIRKWOOD J G . The nuclear magnetic resonance spectrum of ribonuclease[J]. J Am Chem Soc, 1957, 79 (12): 3289- 3290. doi: 10.1021/ja01569a083
13	WILLIAMSON M P , HAVEL T F , WüTHRICH K . Solution conformation of proteinase inhibitor ⅡA from bull seminal plasma by ¹H nuclear magnetic resonance and distance geometry[J]. J Mol Biol, 1985, 182 (2): 295- 315. doi: 10.1016/0022-2836(85)90347-X
14	FAULKNER R A , DIVERDI J A , YANG Y , et al. The surface of nanoparticle silicon as studied by solid-state NMR[J]. Materials, 2013, 6 (1): 18- 46.
15	HOFFMANN H C , DEBOWSKI M , MULLER P , et al. Solid-state NMR spectroscopy of metal-organic framework compounds (MOFs)[J]. Materials, 2012, 5 (12): 2537- 2572. doi: 10.3390/ma5122537
16	LINDON J C , NICHOLSON J K , HOLMES E , et al. Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids[J]. Concept Magnetic Res, 2000, 12 (5): 289- 320. doi: 10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W
17	KENYON W E . Nuclear-magnetic-resonance as a petrophysical measurement[J]. Nucl Geophys, 1992, 6 (2): 153- 171.
18	WISHART D S . Metabolomics: applications to food science and nutrition research[J]. Trends Food Sci Tech, 2008, 19 (9): 482- 493. doi: 10.1016/j.tifs.2008.03.003
19	JIANG Y , DAVID B , TU P , et al. Recent analytical approaches in quality control of traditional Chinese medicines-A review[J]. Anal Chim Acta, 2010, 657 (1): 9- 18. doi: 10.1016/j.aca.2009.10.024
20	BECKER E D . A brief-history of nuclear-magnetic-resonance[J]. Anal Chem, 1993, 65 (6): A295- A302. doi: 10.1021/ac00054a716
21	LAUTERBUR P C . Image formation by induced local interactions: examples employing nuclear magnetic resonance[J]. Nature, 1973, 242 (5394): 190- 191. doi: 10.1038/242190a0
22	MANSFIELD P , GRANNELL P K . NMR diffraction in solids[J]. J Phys C Solid State, 1973, 6 (22): L422- L426. doi: 10.1088/0022-3719/6/22/007
23	SONG Y Q . Low field magnetic resonance: multi-dimensional experiments of relaxation and diffusion[J]. Chinese J Magn Reson, 2015, 32 (2): 141- 149.
	宋一桥. 低场核磁共振: 弛豫和扩散的多维实验[J]. 波谱学杂志, 2015, 32 (2): 141- 149.
24	SUN Z , XIAO L Z , LIAO G Z , et al. Design of magnets for in situ NMR detection devices intended for preservation of ancient architectures[J]. Chinese J Magn Reson, 2017, 34 (3): 372- 382.
	孙哲, 肖立志, 廖广志, 等. 用于长城等古建筑探测的NMR探测器的磁体设计[J]. 波谱学杂志, 2017, 34 (3): 372- 382.
25	ZHANG Z F , XIAO L Z , LIU H X , et al. Simulation of restricted diffusion of water molecules in micropores[J]. Chinese J Magn Reson, 2014, 31 (1): 49- 60. doi: 10.3969/j.issn.1000-4556.2014.01.006
	张宗富, 肖立志, 刘化新, 等. 水分子在微孔隙介质中的受限扩散模拟[J]. 波谱学杂志, 2014, 31 (1): 49- 60. doi: 10.3969/j.issn.1000-4556.2014.01.006
26	HE Y G , FENG J W , ZHANG Z , et al. Development of pulsed dynamic nuclear polarization for enhancing NMR and MRI[J]. Chinese J Magn Reson, 2015, 32 (2): 393- 398.
	贺玉贵, 冯继文, 张志, 等. 脉冲动态核极化增强的NMR和MRI系统研究[J]. 波谱学杂志, 2015, 32 (2): 393- 398.
27	WANG X C , JIANG W L , HUANG C D , et al. Parahydrogen-induced hyperpolarized nuclear magnetic resonance: from basic principle to applications[J]. Spectroscopy and Spectral Analysis, 2020, 40 (3): 665- 673.
	王忻昌, 江文龙, 黄程达, 等. 仲氢诱导超极化增强核磁共振技术: 从原理到应用[J]. 光谱学与光谱分析, 2020, 40 (3): 665- 673.
28	ZHAO X C , SUN X P , YUAN Y P , et al. Measuring polarization of hyperpolarized xenon-129 gas with low-field NMR[J]. Chinese J Magn Reson, 2016, 33 (3): 458- 467.
	赵修超, 孙献平, 袁亚平, 等. 超极化气体氙-129的低场NMR测量[J]. 波谱学杂志, 2016, 33 (3): 458- 467.
29	YANG L , BAO Q J , MAO W P , et al. System performance evaluation of a self-developed NMR spectrometer[J]. Chinese J Magn Reson, 2012, 29 (1): 78- 85.
	杨亮, 鲍庆嘉, 毛文平, 等. 自主研制核磁共振波谱仪的性能评估[J]. 波谱学杂志, 2012, 29 (1): 78- 85.
30	俎栋林. 核磁共振成像仪——构造原理和物理设计[M]. 北京: 科学出版社, 2015.
31	CHEN L , SONG K , WANG Y L . Effects of attenuated salmonella typhimurium infection on fecal metabonome in mice-comparison between WIPM and Bruker 500 MHz NMR spectrometers[J]. Chinese J Magn Reson, 2014, 31 (3): 349- 363. doi: 10.3969/j.issn.1000-4556.2014.03.006
	陈璐, 宋侃, 王玉兰. 感染减毒鼠伤寒沙门氏菌对小鼠粪样代谢组的影响 & mdash; & mdash; WIPM和Bruker 500 MHz核磁共振波谱仪检测结果的比较[J]. 波谱学杂志, 2014, 31 (3): 349- 363. doi: 10.3969/j.issn.1000-4556.2014.03.006
32	QU H Y , WANG L , WANG Y H , et al. Design of the superconducting main magnet based on variable density method in cylindrical MRI scanner[J]. IEEE T Appl Supercon, 2020, 30 (4): 4400805.
33	ZENG Q B , BIE B L , GUO Q N , et al. Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution[J]. P Natl Acad Sci USA, 2020, 117 (30): 17558- 17563. doi: 10.1073/pnas.2004121117
34	LI H D , ZHAO X C , WANG Y J , et al. Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized ¹²⁹Xe MRI[J]. Sci Adv, 2021, 7 (1): eabc8180. doi: 10.1126/sciadv.abc8180
35	ZHAO Z C , LI X , LI S H , et al. Structural investigation of interlayer-expanded zeolite by hyperpolarized ¹²⁹Xe and ¹H NMR spectroscopy[J]. Micropor Mesopor Mat, 2019, 288, 109555. doi: 10.1016/j.micromeso.2019.06.017
36	WANG W Y , HU H , XU J , et al. Hydrogenation reaction on Pd-Cu bimetallic catalysts: A parahydrogen-induced polarization study[J]. Chinese J Magn Reson, 2018, 35 (3): 269- 279.
	王伟宇, 胡涵, 徐君, 等. Pd-Cu双金属催化剂上加氢反应的仲氢诱导超极化研究[J]. 波谱学杂志, 2018, 35 (3): 269- 279.
37	SONG Y H , LIU W Q , YAO Y F . Gaining higher NMR signal enhancement with parahydrogen-induced polarization[J]. Chinese J Magn Reson, 2015, 32 (3): 470- 480.
	宋艳红, 刘文卿, 姚叶锋. 仲氢诱导极化增强的核磁共振实验条件优化[J]. 波谱学杂志, 2015, 32 (3): 470- 480.
38	ARDENKJAER-LARSEN J H . On the present and future of dissolution-DNP[J]. J Magn Reson, 2016, 264, 3- 12. doi: 10.1016/j.jmr.2016.01.015

[1]	邱先鑫,韩旭,汪耀,丁伟娜,孙雅文,周滟,雷皓,林富春. 网络游戏障碍人群大脑功能网络rich club结构的改变[J]. 波谱学杂志, 2022, 39(3): 258-266.
[2]	廖文姗,徐俊成,姚守权,李建奇,蒋瑜. 基于双参考源的数字磁共振控制台相位相干技术[J]. 波谱学杂志, 2022, 39(3): 327-336.
[3]	刘元元, 杨育昕, 朱庆永, 崔卓须, 程静, 刘聪聪, 梁栋, 朱燕杰. 基于多弛豫信号补偿的快速磁共振T_1ρ散布成像[J]. 波谱学杂志, 2022, 39(3): 243-257.
[4]	王颖珊,邓奥琦,毛瑾玲,朱中旗,石洁,杨光,马伟伟,路青,汪红志. 基于3D VNetTrans的膝关节滑膜磁共振图像自动分割[J]. 波谱学杂志, 2022, 39(3): 303-315.
[5]	陈小明, 赵修超, 孙献平, 谢军帅, 李海东, 韩叶清, 刘小玲, 陈琪, 周欣. 超极化¹²⁹Xe自动收集-升华装置研究[J]. 波谱学杂志, 2022, 39(3): 316-326.
[6]	张怡, 楼飞洋, 方可, 陈高, 张孝通. 分子影像新技术——氘代谢波谱及成像的综述与展望[J]. 波谱学杂志, 2022, 39(3): 356-365.
[7]	王振林, 张融, 张妮, 蔺敬旗, 覃莹瑶, 陈刚, 张宫. 一种基于组分补偿的二维核磁共振测井数据高精度处理方法[J]. 波谱学杂志, 2022, 39(2): 174-183.
[8]	马岩, 邢藏菊, 肖亮. 基于级联网络的膝关节图像分割与模型构建[J]. 波谱学杂志, 2022, 39(2): 184-195.
[9]	骆俊, 刘盛平, 杨兴, 王佳升, 李烨. 一种无磁化的5 T磁共振射频功率放大器设计[J]. 波谱学杂志, 2022, 39(2): 163-173.
[10]	胡涵,王伟宇,徐君,邓风. Pd-Sn双金属催化剂催化1, 3-丁二烯加氢反应的仲氢诱导极化研究[J]. 波谱学杂志, 2022, 39(2): 133-143.
[11]	周敏雄, 张会婷, 王一达, 杨光, 姚旭峰, 高安康, 程敬亮, 白洁, 严序. 数据采集方案对神经扩散模型影响的评估[J]. 波谱学杂志, 2022, 39(2): 220-229.
[12]	邱玥, 聂生东, 魏珑. 基于全卷积网络的乳腺肿瘤动态增强磁共振图像分割[J]. 波谱学杂志, 2022, 39(2): 196-207.
[13]	曾姝, 徐舒涛, 魏迎旭, 刘中民. H-SSZ-13分子筛催化乙醇脱水制乙烯反应的原位固体核磁共振研究[J]. 波谱学杂志, 2022, 39(2): 123-132.
[14]	陈雷,刘红兵,刘惠丽. 定量NMR中多种检出限评估方法的比较[J]. 波谱学杂志, 2022, 39(2): 230-242.
[15]	王振宇, 王颖珊, 毛瑾玲, 马伟伟, 路青, 石洁, 汪红志. 基于Dense-UNet++的关节滑膜磁共振图像分割[J]. 波谱学杂志, 2022, 39(2): 208-219.