基于多弛豫信号补偿的快速磁共振T1ρ散布成像

doi:10.11938/cjmr20222976

波谱学杂志 ›› 2022, Vol. 39 ›› Issue (3): 243-257.doi: 10.11938/cjmr20222976

基于多弛豫信号补偿的快速磁共振T_1ρ散布成像

刘元元¹,杨育昕^1,²,朱庆永³,崔卓须³,程静¹,刘聪聪¹,梁栋^1,³,朱燕杰^1,*()

1. 保罗C.劳特伯生物医学成像研究中心, 中国科学院深圳先进技术研究院, 广东深圳 518055
2. 药学与生物工程学院, 重庆理工大学, 重庆 400054
3. 医学人工智能研究中心, 中国科学院深圳先进技术研究院, 广东深圳 518055

收稿日期:2022-02-16 出版日期:2022-09-05 发布日期:2022-04-28
通讯作者: 朱燕杰 E-mail:yj.zhu@siat.ac.cn
基金资助:
中国科学院磁共振技术联盟仪器设备功能开发技术创新项目(2020GZL006);国家重点研发计划课题(2020YFA0712200);广东省基础与应用基础研究基金项目(2021A1515110540);深圳市优秀科技创新人才培养项目(RCYX20210609104444089);中国博士后科学基金面上项目(2020M682990);中国博士后科学基金面上项目(2021M69331);中国博士后科学基金面上项目(2021M703390);广东省磁共振成像与多模系统重点实验室(2020B1212060051)

Accelerating T_1ρ Dispersion Imaging with Multiple Relaxation Signal Compensation

Yuan-yuan LIU¹,Yu-xin YANG^1,²,Qing-yong ZHU³,Zhuo-xu CUI³,Jing CHENG¹,Cong-cong LIU¹,Dong LIANG^1,³,Yan-jie ZHU^1,*()

1. Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
2. Department of Biomedical Engineering, Chongqing University of Technology, Chongqing 400054, China
3. Research Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Received:2022-02-16 Online:2022-09-05 Published:2022-04-28
Contact: Yan-jie ZHU E-mail:yj.zhu@siat.ac.cn

1. 附件材料.pdf(970KB)

摘要/Abstract

摘要：

定量磁共振成像（MRI）可量化组织特性，是科学研究和临床研究的重要工具.旋转坐标系下的自旋-晶格弛豫时间（T_1ρ）能反映水与大分子之间的低频交互作用，在3 T及以上的高场环境下，T_1ρ受水和不稳定质子之间化学交换的影响较大，通过测量弛豫率随自旋锁定场强度的变化而得到其分布情况（T_1ρ散布），可用于分析和量化质子的交换过程，因此T_1ρ散布是一种重要的定量MRI技术.然而，获得不同自旋锁定场强下T_1ρ加权图像的时间过长，限制了其应用范围.针对这一问题，本研究提出一种基于多弛豫信号补偿策略的快速T_1ρ散布成像方法.该方法将不同锁定频率下的T_1ρ加权图像补偿到同一信号强度水平，并结合低秩与稀疏建立重建模型.实验结果表明，该方法在加速倍数高达7倍时仍获得了较好的重建结果.

关键词: 磁共振定量成像, T_1ρ散布, 信号补偿, 低秩与稀疏

Abstract:

Magnetic resonance imaging (MRI) can quantify characteristic values of tissues, serving as an important tool for scientific and clinical research. Magnetic resonance T_1ρ relaxation time reflects the low-frequency motional processes between water and macromolecules. At high fields of 3 T and above, T_1ρ is greatly affected by the chemical exchange between water and exchangeable protons, and T_1ρ dispersion measured with varying spin-lock fields can be utilized to analyze and quantify the proton exchange process. However, it is time-consuming to obtain T_1ρ-weighted images with different spin-lock fields, which limits its application. To solve this problem, a fast T_1ρ dispersion imaging method based on multiple relaxation signal compensation strategy is proposed in this work, which compensates the T_1ρ-weighted images at different locking frequencies to the same signal strength level, and combines the low-rank plus sparse model in the reconstruction. Experimental results show that the proposed method achieves good reconstruction results even when the acceleration factor is up to 7.

Key words: magnetic resonance quantitative imaging, T_1ρ dispersion, signal compensation, low-rank plus sparse

中图分类号:

O482.53

刘元元, 杨育昕, 朱庆永, 崔卓须, 程静, 刘聪聪, 梁栋, 朱燕杰. 基于多弛豫信号补偿的快速磁共振T_1ρ散布成像[J]. 波谱学杂志, 2022, 39(3): 243-257.

Yuan-yuan LIU, Yu-xin YANG, Qing-yong ZHU, Zhuo-xu CUI, Jing CHENG, Cong-cong LIU, Dong LIANG, Yan-jie ZHU. Accelerating T_1ρ Dispersion Imaging with Multiple Relaxation Signal Compensation[J]. Chinese Journal of Magnetic Resonance, 2022, 39(3): 243-257.

图/表 10

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		R=4	R=5	R=6	R=7
nRMSE	L+S	0.0538±0.0144	0.0675±0.0187	0.0835±0.0234	0.1010±0.0232
	BCS	0.0439±0.0180	0.0466±0.0117	0.0562±0.0161	0.0630±0.0166
	T_1ρ-DISC	0.0349±0.0115	0.0383±0.0147	0.0439±0.0169	0.0483±0.0187

PSNR	L+S	17.1353±0.2069	17.0752±0.2686	16.7938±0.3227	16.5361±0.3010
	BCS	17.3670±0.2014	17.4463±0.2431	17.4215±0.2504	17.3205±0.2271
	T_1ρ-DISC	17.5279±0.1981	17.6060±0.2079	17.5362±0.2544	17.4039±0.2585

SSIM	L+S	0.6785±0.0193	0.6408±0.0229	0.6033±0.0261	0.5757±0.0217
	BCS	0.6800±0.0529	0.6727±0.0184	0.6481±0.0219	0.6360±0.0210
	T_1ρ-DISC	0.7148±0.0179	0.7035±0.0223	0.6916±0.0255	0.6853±0.0268

	T_1ρ-DISC	L+S	BCS
R=4	115 min	2 min	932 min
R=5	117 min	3 min	1112 min
R=6	112 min	3 min	898 min
R=7	114 min	3 min	802 min

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基于多弛豫信号补偿的快速磁共振T_1ρ散布成像

Accelerating T_1ρ Dispersion Imaging with Multiple Relaxation Signal Compensation

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基于多弛豫信号补偿的快速磁共振T1ρ散布成像

Accelerating T1ρ Dispersion Imaging with Multiple Relaxation Signal Compensation

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基于多弛豫信号补偿的快速磁共振T_1ρ散布成像

Accelerating T_1ρ Dispersion Imaging with Multiple Relaxation Signal Compensation