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Fast Three-Dimensional Magnetic Resonance Thermometry Using an Echo-Shifted Gradient-Recalled Sequence
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JIANG Rui, ZOU Chao, QIAO Yang-zi, XU Zong-wei, QIU Zhi-lang, LIU Xin, ZHENG Hai-rong
Chinese Journal of Magnetic Resonance, 2019, 36(3): 253-260.
DOI: 10.11938/cjmr20182699
High-intensity focused ultrasound (HIFU) is a noninvasive thermal ablation therapy. Thermometry techniques with high precision and temporal resolution are needed to ensure the safety and effectiveness of HIFU. The magnetic resonance thermometry (MRT) technique based on proton resonance frequency shift (PRFS) shows good linearity with and high sensitivity to temperature change, and is frequently used in HIFU therapy. In practice, HIFU may have a potential danger of causing unwanted skin burns far away from the focus of ultrasound irradiation. It is therefore desirable to increase the spatial coverage of MRT measurements to include the skins. In this work, a fast three-dimensional (3D) MRT technique was developed based on an echo-shifted gradient-recalled sequence with controlled aliasing in volumetric parallel imaging. Phantom experiments were first used to calibrate the accuracy and precision of temperature measurements made by the proposed technique to those obtained by an optical fiber thermometer. Pork tissues were then scanned at room temperature to determine the precision of temperature measurements before and after imaging acceleration. The pork tissues were also scanned under the condition of HIFU heating to compare the accuracy of temperature measurements with or without imaging acceleration.
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Imaging Hippocampus of Mental Patients with BLADE Technique
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SHAO Dan-dan, WANG Xue-xue, PAN Zi-lai, CHEN Ke-min, ZHANG Zhong-shuai, YUAN Li-li, XU Zi-yue, CHEN Lei, WANG Jin-hong
Chinese Journal of Magnetic Resonance, 2019, 36(3): 261-267.
DOI: 10.11938/cjmr20182700
BLADE is the commercial name of a spin-echo imaging technique that uses periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) k -space trajectory. In this study, the efficiency of using BLADE to improve hippocampal imaging in mental patients was assessed. The hippocampi of 47 mental patients were imaged on a 3.0 T scanner along the oblique coronal orientation using the T2 WI TSE and T2 WI FLAIR sequences with or without the use of BLADE. The same four sequences were also used to scan a standard American College of Radiology (ACR) phantom according to the ACR standards. The hippocampal images were scored by two radiologists using a 5-point scale, in terms of motion artifact, pulsation artifact, perceptive coarseness and image quality. The outcomes were compared between the sequences by two-sample Wilcoxon tests. The images of the phantom were evaluated semi-quantitatively for high contrast spatial resolution (HCSR ) and low contrast object detection detectability (LCD ) by counting the number of hole arrays and spokes that could be detected. The results showed that, compared to the conventional sequences, the sequences combined with BLADE technique showed significantly reduced motion and pulsation artifacts (p <0.001), improved image quality (p <0.05), but increased the perceptive coarseness (p <0.001). In the phantom experiments, the use of BLADE greatly improved the LCD , but had little effects on the HCSR . Based on these results, the BLADE technique is recommended for hippocampal imaging in mental patients with low compliance with the guidance.
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Classifying the Course of Alzheimer's Disease with Brain MR Images and a Method Based on Three-Dimensional Local Pattern Transformation
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SUN Jing-wen, YAN Shi-ju, HAN Yong-sen, SONG Cheng-li
Chinese Journal of Magnetic Resonance, 2019, 36(3): 268-277.
DOI: 10.11938/cjmr20182686
A classification method was developed to differentiate cognitive normal controls (CN), mild cognitive impairment (MCI) patients and Alzheimer's disease (AD) patients from the magnetic resonance (MR) image data. Three-dimensional (3D) local pattern transformation was used in the proposed method to obtain texture features, which were then fused with the conventional image features for the classification purposes. Region of interests (i.e., bilateral hippocampus, gray matter and white matter) were selected from the MR images of 46 CN, 61 MCI patients and 25 AD patients, from which the 3D local pattern transformation texture features and conventional image features were extracted, fused and used for classification with the support vector machine. It was demonstrated that the accuracy, sensitivity, specificity and area under the curve (AUC ) were 88.73%, 78.00%, 95.7% and 0.886 5, respectively, for the fused texture feature/conventional image features in bilateral hippocampus of CN controls and AD patients. In comparison, the fused features in the gray matter gave an accuracy, sensitivity, specificity and AUC of 85.92%, 80.00%, 86.6% and 0.854 3, respectively. It is concluded that the texture features extracted from 3D local pattern transform in hippocampus could be used in conjunction with the conventional image features for better classification of the course of Alzheimer's disease.
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A Virtual NMR Spectrometer Based on Numerical Computational Simulations
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WANG Hong-zhi, WANG Shen-lin, HU Bin-wen, YU Yi-hua, SONG Yi-qiao, YAO Ye-feng
Chinese Journal of Magnetic Resonance, 2019, 36(3): 288-297.
DOI: 10.11938/cjmr20182684
Nuclear magnetic resonance (NMR) spectroscopy is an important tool for studying the structures of molecules and materials. Mainly due to their high costs, the NMR spectrometers are often not available for teaching experiments. Teaching NMR experiments cannot be performed routinely and effectively also because that the students are not able to understand the principles underlying the operational steps without proper and adequate training. In this work, a virtual NMR spectrometer (VMRS1.0) for teaching experiments, which is based on numerical computational simulation technology and can be operated like a real spectrometer, is presented. With the VMRS1.0, the students can perform basic NMR experiments, including tuning, shimming, field lock, power adjustment for radio frequency, selecting samples, acquiring data, fast Fourier transform and spectrum processing (i.e., phase correction, integration, chemical shift correction, auto peak finding and J -coupling constant measurement). In addition to the routine one-dimensional NMR experiments, more complicated experiments such as decoupling, DEPT and HMQC can also be performed on the VMRS1.0. With the virtual NMR spectrometer developed, the students can practice their experimental skills and gain deeper understandings of the underlying principles in a more easy and cost-efficient way.
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Evolution of Pore Connectivity in the Fushun Oil Shale by Low-Field Nuclear Magnetic Resonance Spectroscopy
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LIU Zhi-jun, YANG Dong, SHAO Ji-xi, HU Yao-qing
Chinese Journal of Magnetic Resonance, 2019, 36(3): 309-318.
DOI: 10.11938/cjmr20182687
During in-situ exploitation of the oil shale, the connectivity of the pore structure of the reservoir directly affects not only the flow behavior and heat transfer efficiency of the heat-carrying medium, but also the diffusion and flow behaviors of the oil and gas. In this study, the T 2 spectra of saturated water and bound water in samples from the Fushun oil shale were measured with low-field nuclear magnetic resonance at different final pyrolysis temperatures (23~650℃). NMR pore parameters, including T 2 cutoff value of movable fluid, bound fluid porosity, saturated fluid porosity and permeability, were analyzed. The evolution of pore connectivity of the oil shale with final pyrolysis temperature was studied quantitatively. The results demonstrated that final pyrolysis temperature affected the variations of pore connectivity and the permeability of oil shale. The increase of total porosity could be attributed mainly to the increments of movable fluid. These results indicated that increases in final pyrolysis temperature enhanced the permeability and transport of oil and gas, providing a basis for further understanding of the evolution of pore structure in oil shale in-situ pyrolysis.
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Complete Assignments of NMR Spectral Data of Three C19 -Diterpenoid Alkaloids
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YIN Tian-peng, WANG Ya-rong, WANG Min, SHI Wen-zhi, ZHANG Zheng-qian, HE Sha-sha
Chinese Journal of Magnetic Resonance, 2019, 36(3): 331-340.
DOI: 10.11938/cjmr20182694
C19 -diterpenoid alkaloids have complex and diverse structures, posing great challenges for nuclear magnetic resonance (NMR)-based structural elucidation. Three C19 -diterpenoid alkaloids, including taronenine E (1 ), chasmaconitine (2 ) and vilmorisine (3 ), were isolated from the roots of Aconitum taronense Fletcher et Lauener, and analyzed by various NMR spectroscopy methods (i.e., 1 H and 13 C NMR, DEPT, 1 H-1 H COSY, HSQC and HMBC). Complete assignments of the NMR chemical shifts were obtained, providing a good reference for the further research of C19 -diterpenoid alkaloids.
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An NMR Study on Esculetin and It's Derivatives
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LIU Ji-hong, JIN Kun, WANG Ping, LUO Gen
Chinese Journal of Magnetic Resonance, 2019, 36(3): 341-349.
DOI: 10.11938/cjmr20182668
The derivatives of esculetin contain hydroquinone groups that have various biological activities. In this study, the esculetin derivatives 2~14 were obtained by inducting the methoxy and hydroxyl groups into the 5, 6, 7 and 8 positions, and pheny group into the 4 position of esculetin (1 ), respectively. The structures of these derivatives were analyzed by the combined use of a number of nuclear magnetic resonance (NMR) spectroscopy techniques, including 1 H and 13 C NMR, 1 H-13 C HSQC and 1 H-13 C HMBC. The 1 H and 13 C NMR chemical shifts of the compounds were assigned. The effects of different substituents on the chemical shifts were discussed. The NMR shifts of esculetin derivatives were also calculated using the quantum chemical calculation method of gauge-invariant atomic orbitals (GIAO) and continuous set of gauge transformations (CSGT). And the calculated 1 H and 13 C NMR chemical shifts were compared with their experimental values.
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Spectral Analyses and Structural Elucidation of Azilsartan
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WANG Ya-lan, WANG Xiao-jing, WANG Zhi-wei
Chinese Journal of Magnetic Resonance, 2019, 36(3): 350-358.
DOI: 10.11938/cjmr20182689
Azilsartan is a novel AT-1 angiotensin Ⅱ receptor blocker, which reduces blood pressure mildly without the side effect of cough. The drug is believed to have a large market potential. In this study, the drug was analyzed by ultraviolet spectroscopy (UV), infrared spectroscopy (IR), high resolution mass spectrometry (HRMS) and one-/two-dimensional magnetic resonance spectroscopy (i.e., 1 H NMR, 13 C NMR, DEPT, 1 H-1 H COSY, HMQC and HMBC). The spectral data were carefully analyzed, interpreted and used to elucidate the structure of the compound.
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Application of Quantum Chemical Calculation of Nuclear Magnetic Resonance Parameters in the Structure Elucidation of Natural Products
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HU Kun, SUN Han-dong, PUNO Pema-tenzin
Chinese Journal of Magnetic Resonance, 2019, 36(3): 359-376.
DOI: 10.11938/cjmr20182682
With the continuous development of quantum chemical theories and advances in computer hardware and software, the methods for quantum chemical calculation of nuclear magnetic resonance parameters (qcc-NMR) are improved significantly in the past decade. With these methods, accurate calculated results can often be obtained at a relatively low cost. Furthermore, the methods for result analysis have been advanced from simple statistical parameters to more sophisticated procedures based on more complicated statistical methods or artificial neuron networks, etc. These advances make qcc-NMR a significant complement to traditional spectrometric methods, and more and more useful in natural product research. In this paper, the application of qcc-NMR in natural product research is reviewed. Representative researches featuring the use of qcc-NMR are highlighted.
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Progress of Right Ventricle Segmentation from Short-Axis Images Acquired with Cardiac Cine MRI
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SU Xin-yu, WANG Li-jia, NIE Sheng-dong, HU Li-wei, ZHONG Yu-min
Chinese Journal of Magnetic Resonance, 2019, 36(3): 377-391.
DOI: 10.11938/cjmr20182678
Right ventricle (RV) segmentation is essential for assessing cardiac function in patients with pulmonary hypertension, tetralogy of Fallot, and so on. However, it remains difficult due to the complex structure of heart, thin myocardium and large variability of the RV, as well as the interferences from the fat nearby. Due to its high temporal and spatial resolution, cardiac cine magnetic resonance imaging is widely used for functional evaluation of the heart. This article reviews the commonly-used methods for RV segmentation from the cardiac cine magnetic resonance images. The traditional algorithms are described first, followed by the novel multi-atlas and deep learning methods. Lastly, the evaluation standards for RV segmentation are introduced. It is concluded that the deep learning-based segmentation methods may have the potential to become the method of choice in clinical settings due to their high efficiency and accuracy in the diagnosis and prognosis of the heart-related diseases.