Chinese Journal of Magnetic Resonance ›› 2025, Vol. 42 ›› Issue (2): 184-194.doi: 10.11938/cjmr20243125cstr: 32225.14.cjmr20243125

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NMR Data Analysis of Acarbose

LI Yujiang1, ZHAO Wei1, TAO Le1, LU Bohua1, ZHENG Guo1, ZHANG Haiyan2,*(), GUO Xiaohe1,#(), ZHAO Tianzeng1,2   

  1. 1. High&New Technology Research Center of Henan Academy of Sciences, Zhengzhou, 450002, China
    2. Key Laboratory of Natural Products, Henan Academy of Sciences, Zhengzhou, 450002, China
  • Received:2024-08-01 Published:2025-06-05 Online:2024-09-29
  • Contact: *Tel: 0371-65511668, E-mail: haiyanhai6828_cn@sina.com;# Tel: 0371-65511776, E-mail: guoxiaohecn@126.com.

Abstract:

Acarbose, an α-glucosidase inhibitor, has been widely used in the treatment of type-II diabetes due to its unique mechanism of action. In this study, comprehensive and accurate 1H and 13C NMR data of acarbose in DMSO-d6, including 1H NMR data of all hydroxyl groups of acarbose as well as 1H and 13C NMR data of the dual signal of C-ring α and β, were reported for the first time. The assignment of 1H and 13C NMR data was conducted using DEPT-135, 1H-1H COSY, 1H-13C HSQC, and 1H-13C HMBC techniques. The molecular structure of acarbose was confirmed, providing a reliable data basis for the safety and quality control of acarbose drugs.

Key words: liquid-state NMR, structural assignment, 2D NMR, acarbose

CLC Number: