NMR Data Analysis of Manidipine Hydrochloride

doi:10.11938/cjmr20202853

Abstract

Abstract: Manidipine hydrochloride is the third generation of new synthetic antihypertensive drugs. The structure of manidipine hydrochloride was confirmed with 1D and 2D nuclear magnetic resonance (NMR) techniques, such as ¹H NMR, ¹³C NMR, DEPT-135, ¹H-¹H COSY, ¹H-¹H NOESY, ¹H-¹³C HSQC, and ¹H-¹³C HMBC. Some abnormal signals in ¹H NMR and ¹³C NMR spectra were further discussed.

Key words: liquid-state NMR, structural elucidation, 2D NMR, manidipine hydrochloride, quadrupolar relaxation of ¹⁴N nucleus

CLC Number:

O656.4

LI Yu-jiang, ZHAO Wei, GUO Xiao-he, TAO Le, ZHANG Xiang, ZHANG Hai-yan, ZHAO Tian-zeng. NMR Data Analysis of Manidipine Hydrochloride[J]. Chinese Journal of Magnetic Resonance, 2021, 38(1): 110-117.

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