波谱学杂志

• 研究简报 • 上一篇    下一篇

奥利司他的有机波谱分析

陈再新*,于水涛,夏正君   

  1. 江苏亚邦药业集团 技术中心,江苏 常州 213200
  • 收稿日期:2013-04-08 修回日期:2013-07-13 出版日期:2013-12-05 发布日期:2013-12-05
  • 作者简介:陈再新(1970-),男,安徽池州人,高级工程师,从事新药的研究开发及原料药合成工艺研究. 电话: 0519-82313163,E-mail: zaixin_chen@163.com.*通讯联系人.

Spectroscopic Characterization of Orlistat

CHEN Zai-xin*,YU Shui-tao,XIA Zheng-jun   

  1. R&D Center, Jiangsu Yabang Pharmaceutical Group, Changzhou 213200, China
  • Received:2013-04-08 Revised:2013-07-13 Online:2013-12-05 Published:2013-12-05
  • About author:*Corresponding author: Chen Zai-xin, Tel: 051982313163,E-mail: zaixin_chen@163.com.

摘要:

减肥药奥利司他是一种强效的特异性胃肠道脂肪酶抑制剂,应用NMR、ESI-MS、UV和IR对其结构进行了确证,采用DEPT、COSY、HMBC和HSQC技术对其 1H NMR和13C NMR谱的信号进行了归属.

关键词: 核磁共振(NMR), 归属, 红外光谱, 紫外光谱, 奥利司他, 结构确证

Abstract:

Orlistat is a potent and specific inhibitor of gastric and pancreatic lipases. The structure of orlistat was identified by a series of spectroscopic techniques including NMR, UV and IR. The 1H  and 13C NMR signals of orlistat were assigned by DEPT, COSY, HMBC and HSQC.

Key words: NMR, assignment, infrared, ultraviolet, orlistat, structure

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