波谱学杂志 ›› 2018, Vol. 35 ›› Issue (1): 90-97.doi: 10.11938/cjmr20172583

• 研究简报 • 上一篇    下一篇

两个C19-二萜生物碱的结构鉴定和NMR信号归属

尹田鹏1,2, 陈阳1, 罗萍2, 蔡乐2, 丁中涛2   

  1. 1. 遵义医学院珠海校区, 珠海市中药基础及应用研究重点实验室, 广东 珠海 519041;
    2. 云南大学 化学科学与工程学院, 云南省高校功能分子分析与生物转化重点实验室, 云南 昆明 650091
  • 收稿日期:2017-05-30 出版日期:2018-03-05 发布日期:2018-03-05
  • 通讯作者: 蔡乐,Tel:0871-65033719,E-mail:caile@ynu.edu.cn. E-mail:caile@ynu.edu.cn
  • 基金资助:
    The national natural science foundation of China (81460648); Graduate student quality curriculum of Yunnan university.

Structural Elucidation and NMR Spectral Assignments of Two C19-Diterpenoid Alkaloids

YIN Tian-peng1,2, CHEN Yang1, LUO Ping2, CAL Le2, DING Zhong-tao2   

  1. 1. Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zunyi Medical University Zhuhai Campus, Zhuhai 519041, China;
    2. Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
  • Received:2017-05-30 Online:2018-03-05 Published:2018-03-05
  • Supported by:
    The national natural science foundation of China (81460648); Graduate student quality curriculum of Yunnan university.

摘要: 从剑川乌头(Aconitum handelianum)的根中分离得到两个C19-二萜生物碱:高展花乌头宁(homochasmanine,化合物1)和14-去苯甲酰大渡乌碱(14-debenzoylfranchetine,化合物2).采用1D和2D核磁共振(NMR)技术(包括1H NMR、13C NMR、DEPT、1H-1H COSY、HSQC、HMBC和NOESY)对其进行结构鉴定,完整归属了这两个化合物的1H和13C NMR信号.

关键词: 核磁共振(NMR), 鉴定, 归属, 二萜生物碱, 剑川乌头(Aconitum handelianum)

Abstract: Two C19-diterpenoid alkaloids, homochasmanine (compound 1) and 14-debenzoylfranchetine (compound 2), were isolated from the roots of Aconitum handelianum. Their structures were elucidated by one-dimensional and two-dimensional nuclear magnetic resonance (NMR) techniques, including 1H NMR, 13C NMR, DEPT, 1H-1H COSY, HSQC, HMBC and NOESY. The 1H and 13C NMR signals of the compounds were completely assigned.

Key words: NMR, elucidation, assignment, diterpenoid alkaloid, Aconitum handelianum

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