核磁共振技术测量生物骨密度的设备及方法

doi:10.11938/cjmr20160312

波谱学杂志 ›› 2016, Vol. 33 ›› Issue (3): 468-478.doi: 10.11938/cjmr20160312

• 低场磁共振技术与应用专栏 • 上一篇下一篇

核磁共振技术测量生物骨密度的设备及方法

李成伟¹, 范东伟², 姜佳岐¹, 杜国红³, 王为民¹

1. 北京大学信息科学技术学院量子电子学研究所, 北京 100871;
2. 北京大学首钢医院, 北京 100144;
3. 北京大学第三医院, 北京 100191

收稿日期:2016-03-15 修回日期:2016-07-11 出版日期:2016-09-05 发布日期:2016-09-05
通讯作者: 王为民,电话:010-62755054,E-mail:wmwang@ele.pku.edu.cn. E-mail:wmwang@ele.pku.edu.cn
作者简介:李成伟(1990-),男,江苏泰州人,硕士研究生,无线电物理专业.
基金资助:
国家重点基础研究发展计划（“973计划”）资助项目（2015CB250902），国家自然科学基金资助项目（61531002）.

Measuring Bone Mineral Density with NMR

LI Cheng-wei¹, FAN Dong-wei², JIANG Jia-qi¹, DU Guo-hong³, WANG Wei-min¹

1. Institute of Quantum Electronics, School of Electronics Engineering and Computer Science, Peking University, Beijing 100871, China;
2. Shougang Hospital, Peking University, Beijing 100144, China;
3. Peking University Third Hospital, Beijing 100191, China

Received:2016-03-15 Revised:2016-07-11 Online:2016-09-05 Published:2016-09-05

摘要/Abstract

摘要：

诊断骨质疏松症多采用双能X射线吸收方法测得的骨密度数据作为依据，但是该方法存在一定量的辐射，且准确性不高. 该文设计并改进了一套核磁共振装置，通过在发射和接收线圈之间增加快速切换开关（Q-switch），使得核磁共振自旋回波的回波时间缩短至80 ms的超短回波时间范围，实现了对T₂弛豫时间很短的骨组织核磁共振自旋回波信号的采集；将T₂弛豫时间谱和双能X射线方法测量的骨密度数据进行了对比研究，发现核磁共振T₂弛豫时间谱上300~500 ms之间的峰值与骨密度之间具有良好的线性关系，随着骨密度的增大，相应的T₂弛豫时间峰值缩短；利用核磁共振T₂弛豫时间谱技术，结合双能X射线吸收方法，提出了一种测量生物离体骨骼样本骨密度的方法. 该测量方案具有测量速度快、对人体完全无害、跨时期比较性强等优点，很好的弥补了现有测量方法的不足，在骨质疏松症的诊断和疗效评估中有着良好的应用前景.

关键词: 核磁共振, T₂弛豫时间谱, 双能X射线吸收, 超短回波时间, 骨密度

Abstract:

Bone mineral density (BMD) measured by dual energy X-ray absorptiometry is often used as an index for diagnosis of osteoporosis. However, ionization radiation is present in X-ray BMD measurement, and the result can be inaccurate in some caese. In this work, we constructed an NMR equipment that used a Q-switch to achieve echo time as low as 80 ms, and thus have the potential to be used for BMD measurement. In the T₂ relaxation time spectra of bone measured by this equipment, the peak area at 300~500 ms was found to change linearly with the BMD measured by X-ray absorptiometry. Based on this observation, we put forward a method to measure in vitro BMD with NMR T₂ relaxation time spectra. This kind of method has advantages such as high measuring speed, no ionization radiation, and high cross-period comparability.

Key words: NMR, T₂ relaxation time spectrum, dual energy X-ray absorptiometry, ultra-short echo time, bone mineral density

中图分类号:

李成伟, 范东伟, 姜佳岐, 杜国红, 王为民. 核磁共振技术测量生物骨密度的设备及方法[J]. 波谱学杂志, 2016, 33(3): 468-478.

LI Cheng-wei, FAN Dong-wei, JIANG Jia-qi, DU Guo-hong, WANG Wei-min. Measuring Bone Mineral Density with NMR[J]. Chinese Journal of Magnetic Resonance, 2016, 33(3): 468-478.

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核磁共振技术测量生物骨密度的设备及方法

Measuring Bone Mineral Density with NMR

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