核磁共振脉冲序列发生器研究进展

波谱学杂志 ›› 2012, Vol. 29 ›› Issue (3): 339-345.

• 磁共振谱仪研制技术进展专栏 • 上一篇下一篇

核磁共振脉冲序列发生器研究进展

张志^1,2，毛文平^1,2，刘朝阳^1*

1. 波谱与原子分子物理国家重点实验室，武汉磁共振中心（中国科学院武汉物理与数学研究所），湖北武汉 430071； 
2. 中国科学院研究生院，北京 100049

收稿日期:2011-10-09 修回日期:2011-12-05 出版日期:2012-09-05 发布日期:2012-09-05
基金资助:
国家自然科学基金资助项目(10675162)，国家科技支撑计划资助项目(2006BAK03A22).

Progress in the Development of Pulse Programmer for Nuclear Magnetic Resonance

ZHANG Zhi^1,2, MAO Wen-Ping^1,2, LIU Chao-Yang^1*

1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance (Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;
2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

Received:2011-10-09 Revised:2011-12-05 Online:2012-09-05 Published:2012-09-05
Supported by:
国家自然科学基金资助项目(10675162)，国家科技支撑计划资助项目(2006BAK03A22).

摘要/Abstract

摘要：

介绍了核磁共振脉冲序列发生器的基本结构和工作原理，从系统集成度、数据传输速率和序列存储容量等方面出发，着重探讨了近年来核磁共振脉冲序列发生器研究的进展情况，分析比较了商用和自主研发的脉冲序列发生器的优点和亟待解决的问题，并针对这些问题提出了基于USB 3.0的模块化脉冲序列发生器设计方案，该方案可以为多收发通道核磁共振成像仪的研制提供参考.

关键词: 核磁共振(NMR), 脉冲序列发生器, PCI-104, FPGA, USB 3.0

Abstract:

Basic structure and work flow of pulse programmer in NMR spectrometer were introduced. The progress of pulse programmer in terms of degree of system integration, rate of data transmission and memory capacity was emphasized. The advantages and disadvantages of commercial and home-build pulse programmers were compared. A modularized pulse programmer based on USB 3.0 was proposed, which might be used in magnetic resonance imaging (MRI) scanners with multichannel transceivers.

Key words: NMR, pulse programmer, PCI-104, FPGA, USB 3.0

中图分类号:

O482.53

张志, 毛文平, 刘朝阳. 核磁共振脉冲序列发生器研究进展[J]. 波谱学杂志, 2012, 29(3): 339-345.

ZHANG Zhi, MAO Wen-Ping, LIU Chao-Yang. Progress in the Development of Pulse Programmer for Nuclear Magnetic Resonance[J]. Chinese Journal of Magnetic Resonance, 2012, 29(3): 339-345.

参考文献

[1] Adduci D J, Gerstein B C. Versatile pulse programmer for nuclear magnetic-resonance[J]. Rev Sci Instrum, 1979, 50(11): 1 403-1 415.

[2] Dart J, Burum D P, Rhim W K. Highly flexible pulse programmer for NMR applications[J]. Rev Sci Instrum, 1980, 51(2): 224-228.

[3] Danese G, Dotti D, Jian H G, et al. Word programmer for NMR[J]. Rev Sci Instrum, 1986, 57(7): 1 349-1 353.

[4] Toyoda T, Yoshida H, Oishi O, et al. Personal computer-controlled 16 channel versatile pulse generator for nuclear magnetic resonance[J]. Rev Sci Instrum, 1997, 68(8): 3 140-3 142.

[5] Ambrosetti R, Ranieri G A, Ricci D. Data acquisition and pulse generation system for nuclear magnetic resonance spectrometers on a single PC-ISA compatible board[J]. Meas Sci Technol, 1998, 9(8): 1 303-1 310.

[6] Belmonte S B, Oliveira I S, Guimaraes A P. Graphical programming for pulse automated NMR experiments[J]. Meas Sci Technol, 1998, 9(12): 1 951-1 955.

[7] Belmonte S B, Sarthour R S, Oliveira I S, et al. A field-programmable gate-array-based high-resolution pulse programmer[J]. Meas Sci Technol, 2003, 14(1): N1-N4.

[8] Handa S, Domalain T, Kose K. Single-chip pulse programmer for magnetic resonance imaging using a 32-blit microcontroller[J]. Rev Sci Instrum, 2007, 78(8): 84 705.

[9] Shen Jie(沈杰), Xu Qin(徐勤), Tao Hong-yan(陶红艳), et al. A PC Based Pulse Sequence Generator(基于PC机的脉冲序列发生器)[J]. Chinese J Magn Reson(波谱学杂志), 2003, 20(02): 149-154.

[10] Kyburz R. VNMR Pulse Sequences: Programming and Hardware Aspects[EB/OL]. Varian, Inc, 1998.

[11] Ji Wen-bin(季文彬), Qiao Yong(乔勇), Lei Du(雷都), et al. Hardware design for a general-purpose pulse generator used in NMR spectrometers(通用硬件脉冲序列发生器的研制)[J]. Chinese J Magn Reson(波谱学杂志), 2007, 24(03): 321-327.

[12] Butler E. AVANCE III NMR Hardware User Guide[EB/OL]. Bruker Biospin GmbH, 2008.

[13] Mao W P, Bao Q J, Yang L, et al. A modularized pulse programmer for NMR spectroscopy[J]. Meas Sci Technol, 2011, 22(2): 025901.

[14] Wachter E A, Sidky E Y, Farrar T C. Enhanced state-machine pulse programmer for very-high-precision pulse programming[J]. Rev Sci Instrum, 1988, 59(10): 2 285-2 289.

[15] Silva A C, Merkle H. Hardware considerations for functional magnetic resonance imaging[J]. Concept Magn Reson Part A, 2003, 16A(1): 35-49.

[16] Vaughan T, Delabarre L, Snyder C, et al. 9.4 T human MRI: Preliminary results[J]. Magnet Reson Med, 2006, 56(6): 1 274-1 282.

[17] Han Xu(韩旭). An 512MSDRAM based Pulse Sequence Generator For Magnetic Resonance Imaging(基于512MSDRAM的脉冲序列发生器)[D]. Shanghai(上海): East China Normal University(华东师范大学), 2010.

[18] Hu Peng(胡鹏). Design and Implementation of NMR Spectrometer Receiver(核磁共振波谱仪接收机的设计与实现)[D]. Wuhan(武汉): Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences(中国科学院武汉物理与数学研究所), 2010.

[19] Hewlett-Packard Company, Intel Corporation, Microsoft Corporation, et al. Universal Serial Bus 3.0 Specification[S]. Revision 1.0. 2011: June 6, 2011.

[20] Altera Corporation. Quartus II Version 7.2 Handbook Volume 5:Embedded Peripherals[EB/OL]. Altera Corporation, 2007.

核磁共振脉冲序列发生器研究进展

Progress in the Development of Pulse Programmer for Nuclear Magnetic Resonance

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	胡坤, 孙汉董, 普诺·白玛丹增. 量子化学计算核磁共振参数在天然产物结构鉴定中的应用[J]. 波谱学杂志, 2019, 36(3): 359-376.
[2]	尹田鹏, 王雅溶, 王敏, 石文智, 张正茜, 何莎莎. 三个C₁₉-二萜生物碱的NMR数据全归属[J]. 波谱学杂志, 2019, 36(3): 331-340.
[3]	杨云汉, 杜瑶, 应飞祥, 杨俊丽, 夏大真, 夏福婷, 杨丽娟. 柚皮素/β-环糊精超分子体系的包合行为[J]. 波谱学杂志, 2019, 36(3): 319-330.
[4]	王亚兰, 王晓静, 王志伟. 阿齐沙坦的波谱学数据及结构确证[J]. 波谱学杂志, 2019, 36(3): 350-358.
[5]	曹园, 吴永平, 陈东军. 卷柏属Selaginellin类化合物互变异构的波谱学研究[J]. 波谱学杂志, 2019, 36(2): 155-163.
[6]	寇新慧, 刘乙祥, 刘兴弘, 李从刚, 刘买利, 姜凌. 探测应答调控蛋白PhoB_N^F20D自由态中存在的Pre-Active构象[J]. 波谱学杂志, 2019, 36(2): 164-171.
[7]	陈晓瑛, 俞刚金, 毛诗珍, 刘买利, 杜有如. 利用¹H NMR探究混合离子型/非离子型表面活性剂临界胶束浓度降低的实质[J]. 波谱学杂志, 2019, 36(2): 219-224.
[8]	尹田鹏, 罗智慧, 蔡乐, 丁中涛. 天然C₁₉-二萜生物碱的研究进展及其核磁共振波谱特征[J]. 波谱学杂志, 2019, 36(1): 113-126.
[9]	冉梦琳, 覃凌云, 唐淳, 董旭. 磷酸化调控泛素单体与Rad23A/Ubiquilin-1中泛素结合域互作的检测[J]. 波谱学杂志, 2019, 36(1): 15-22.
[10]	魏会强, 于江, 毕常芬, 宁洪鑫, 李祎亮, 刘强. N-异丁酰基-3'-O-(1-氟-1,1,3,3-四异丙基-1,3-二硅氧烷-3-基)-2'-苄氧羰基鸟苷的NMR研究[J]. 波谱学杂志, 2019, 36(1): 93-102.
[11]	李英俊, 杨凯栋, 靳焜, 刘季红, 王思远, 张楠. 基于咔唑-靛红双-硫代碳酰腙衍生物的NMR研究[J]. 波谱学杂志, 2019, 36(1): 83-92.
[12]	迟秀娟, 乔晓亚, 刘颖, 刘惠丽, 陈雷, 王际辉, 艾选军. 拟南芥AtGrp7 RRM结构域的纯化及其结构与结合的初步分析(英文)[J]. 波谱学杂志, 2019, 36(1): 1-14.
[13]	尹田鹏, 汪泽, 陈阳, 邵娅婷, 邓亮, 黎唯. 10-吲哚细胞松弛素chaetoglobosin F的NMR解析[J]. 波谱学杂志, 2019, 36(1): 74-82.
[14]	黄朝晖, 张志, 陈黎, 陈俊飞, 张震, 陈方, 刘朝阳. MRI梯度预加重模块的分时复用设计[J]. 波谱学杂志, 2018, 35(4): 465-474.
[15]	王伟宇, 胡涵, 徐君, 邓风. Pd-Cu双金属催化剂上加氢反应的仲氢诱导超极化研究[J]. 波谱学杂志, 2018, 35(3): 269-279.