大脑能量代谢和神经传递动力学的NMR测定方法

摘要/Abstract

摘要：

能量代谢和神经传递是生命的基石，它们与所有神经性和精神性疾病都有互为因果的关系，因此其研究对于脑功能的认识具有重要意义. 正常情况下，葡萄糖代谢是大脑能量的主要来源，但定量描述大脑内糖类物质与神经传递动力学参数的研究方法是该领域内的一个瓶颈问题. 核磁共振（NMR）方法以其特有的优势迅速成为该研究领域内的重要的研究工具. 本文重点旨在对大脑中能量代谢和神经传递动力学进行研究的NMR技术、方法及其应用进行较详细的介绍.

关键词: 核磁共振(NMR), 能量代谢, ¹H-[¹³C]-NMR, 神经传递动力学, 三羧酸循环

Abstract:

Energy metabolism and neurotransmission are fundamental to all brain functions and their abnormalities are invariably the causes of various neurogenic or psychotic diseases. Therefore, understanding energy metabolism and neurotransmission has long been one of the major topics in the brain research, particularly essential for revealing the mechanism of brain functions. While it is well-known that glucose is the main energy source of the brain, it has been difficult to quantitatively measure the metabolic kinetics and the neurotransmission in vivo. Owing to their unique advantages, nuclear magnetic resonance (NMR) method has quickly emerged as one type of the most important tool in the field. In this paper, the principle and techniques of the relevant NMR methods as well as their applications in the studies of metabolic kinetics and neurotransmission are comprehensively reviewed.

Key words: NMR, energy metabolism, ¹H-[¹³C]-NMR, , neurotransmission kinetics, , tricarboxylic acid cycle

中图分类号:

O482.53

王杰, 刘青, 姜立红, 徐富强. 大脑能量代谢和神经传递动力学的NMR测定方法[J]. 波谱学杂志, 2010, 27(3): 341-354.

WANG Jie, LIU Qing, JIANG Li-Hong, XU Fu-Qiang. NMR method for Determining Energy Metabolism and Neurotransmission Kinetics in Brain[J]. Chinese Journal of Magnetic Resonance, 2010, 27(3): 341-354.

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