[1]  Durante M, Manti L. Human response to high-background radiation environments on earth and in space
[J]. Adv Space Res, 2008, 42: 999-1 000. 

[2]  Nelson G A. Fundamental space radiobiology[J]. Gravit Space Biol Bull, 2003, 16: 29-36. 

[3]  Shukitt-Hale B, Gemma C, Amanda N C, et al. Exposure to ⁵⁶Fe irradiation accelerates normal brain aging and produces deficits in spatial learning and memory[J]. Adv Space Res, 2007, 39: 1 087-1 092. 

[4]  Durante M, Ando K, Furusawa Y, et al. Complex chromosomal rearrangements induced in vivo by heavy ions. Cytogenet Genome Res, 2004, 104 (1-4): 240-244. 

[5]  Peter G, Marcelo E V. Cytotoxic and cell cycle effects in human neuronal progenitor cells exposed to 1 GeV/nFe ions[J]. Adv Space Res, 2007, 39: 1 004-1 010. 

[6]  Sannita W G, Acquaviva M, Ball S L, et al. Effects of heavy ions on visual function and electrophysiology of rodents: the ALTEA-MICE project[J]. Adv Space Res, 2004, 33: 1 347-1 351.

[7]  Sannita W G,  Narici L, Picozza P. Positive visual phenomena in space: A scientific case and a safety issue in space travel[J]. Vision Res, 2006, 46: 2 159-2 165. 

[8]  Kiefer J, Der S, Justus L U. Mutagenic effects of heavy charged particles[J]. J Radiat Res, 2002, 43(Suppl.): S21-S25. 

[9]  Siuzdak G. Biochemistry’s new look[J]. Nature, 2008, 455: 697-700. 

[10]  Tang H R, Wang Y L. Metabonomics: a Revolution in Progress[J]. Prog Biochem Biophys, 2006, 33(5): 401-417. 

[11]  Nicholson J K, Lindon J C, Holmes E. ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
[J]. Xenobiotica, 1999, 29(11): 1 181-1 189.

[12]  Fiehn O, Kopka J, Dormann P, et al. Metabolite profiling for plant functional genomics[J]. Nat Biotechnol, 2000, 18(11): 1 157-1 161.

[13]  Pears M R, Cooper J D, Mitchison H M, et al. High resolution ¹H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of batten disease[J]. J Bio Chem, 2005, 280(52): 42 508-42 514.

[14]  Ignasi B, Rafael F M, David C D, et al. Alzheimer’s disease beyond the genomic era: nuclear magnetic resonance(NMR) spectroscopy-based metabolomics[J]. J Cell Mol Med, 2008, 12(5): 1 477-1 485.

[15]  Moussa C E -H, Rae C, Bubb W A, et al. Inhibitors of glutamate transport modulate distinct patterns in brain metabolism[J]. J Neuroscience Res, 2007, 85: 342-350. 

[16]  Yoshida H, Yamazaki J, Ozawa S, et al. Advantage of LC-MS metabolomics methodology targeting hydrophilic compounds in the studies of fermented food samples[J]. J Agric Food Chem, 2009, 57(4): 1 119-1 126.

[17]  Zha W J, Rubin-Pitel S B, Shao Z Y, et al. Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering[J]. Metab Eng, 2009, 11: 192-198. 

[18]  Miller M G. Environmental metabolomics: a SWOT analysis (Strengths, Weaknesses, Opportunities, and Threats)[J]. J Proteome Res, 2007, 6: 540-545.

[19]  Eleanor A B, Polly Y C. A review of ground-based heavy ion radiobiology relevant to space radiation risk assessment: Cataracts and CNS effects[J]. Adv Space Res, 2007, 40: 1 307-1 319.

[20]  Rabin B M, Joseph J A, Shukitt-Hale B. Heavy particle irradiation, neurochemistry and behavior: thresholds, doseresponse curves and recovery of function[J]. Adv Space Res, 2004, 33: 1 330-1 333.

[21]  Rabin B M, Joseph J A, Shukitt-Hale B, et al. Effects of exposure to heavy particles on a behavior mediated by the dopaminergic system[J]. Adv Space Res, 2000, 25(10): 2 065-2 074.

[22]  Shukitt-Hale B, Gema C, Cantuti-Castelvetri I, et al. Cognitive deficts induced by ⁵⁶Fe radiation exposure[J]. Adv Space Res, 2003, 31(1): 119-126.

[23]  Belle J E L, Harris N G, Williams S R, et al. A comparision of cell and tissue extraction techniques using highresolution ¹H NMR spectroscopy[J]. NMR Biomed, 2002, 15: 37-44. 

[24]  Sonnewald U, Petersen S B, Krane J, et al. ¹H NMR study of cortex neurons and cerebellar granule cells on microcarriers and their PCA extracts: lactate production under hypoxia[J]. Magn Reson Med, 1992, 23: 166-171. 

[25]  Pears M R, Cooper J D, Mitchison H M, et al. High resolution ¹H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease[J]. J Biol Chem, 2005, 280: 42 508-42 514. 

[26]  Yap I K S, Clayton T A, Tang H R, et al. An integrated metabonomic approach to describe temporal metabolic disregulation induced in the rat by the model hepatotoxin allyl formate[J]. J Proteome Res, 2006, 5: 2 675-2 684.

[27]  Zhang X R, Liu H L, Wu J F, et al. Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats[J]. Neurochem Int, 2009, 54: 481-487.

[28]  Mark R V, Bruce G L, Marion G M, et al. An NMR metabolomic investigation of early metabolic disturbances following traumatic brain injury in a mammalian model[J]. NMR Biomed, 2005, 18: 507-516.

[29]  Spoerri P E. Neurotrophic effects of GABA in cultures of embryonic chick brain and retina[J]. Synapse, 1988, 2(1): 11-22.