波谱学杂志 ›› 2009, Vol. 26 ›› Issue (2): 247-254.

• 研究论文 • 上一篇    下一篇

增强低场下脑功能磁共振成像显著性的研究

杨萍1,2*; 王金星1; 晁月盛1   

  1. (1.东北大学 理学院,辽宁 沈阳 110004;2.东软飞利浦医疗设备系统有限责任公司MR研发部,辽宁 沈阳 110179
  • 收稿日期:2008-08-22 修回日期:2008-09-28 出版日期:2009-06-05 发布日期:2009-12-05
  • 通讯作者: 杨萍

Functional Magnetic Resonance Imaging at 0.35 T Using SEEP Contrast

YANG Ping1,2*; WANG Jin-xing1; CHAO Yue-sheng1   

  1. (1.College of Science, Northeastern University, Shenyang 110004, China; 
    2.MRI R&D Division, Philips and Neusoft Medical Systems Co., Ltd. Shenyang 110179, China)
  • Received:2008-08-22 Revised:2008-09-28 Online:2009-06-05 Published:2009-12-05
  • Contact: YANG Ping

摘要: 实现了基于低场0.35 T磁共振成像系统的大脑功能磁共振成像(functional Magnetic Resonance Imaging,fMRI)的研究. 基于质子密度加权的快速自旋回波(Turbo Spin Echo,TSE)图像,重点研究增强低场fMRI显著性的方法,目的在于提高低场fMRI的可用性. 结果表明:健康受试者在执行手动任务期间,大脑运动区的信号强度变化可以由基于血管外质子信号增强 (Signal Enhancement by Extravascular water Protons,EEP)的对比机制探测. 优化TSE序列参数能提高图像SNR和扫描速度,并在统计分析中增加外在屏蔽图像,可以有效地提高低场下fMRI研究结果的显著性.

关键词: 功能磁共振成像(fMRI), 磁共振成像(MRI), SEEP对比, 低场MRI

Abstract: Functional magnetic resonance imaging (fMRI) was performed on a low magnetic field strength (0.35 T) MRI system using a protondensity weighted turbo spin-echo (TSE) imaging sequence. Healthy human volunteers performed a finger taping task, and the brain activations during the task were monitored. The results demonstrated that task-induced signal intensity changes in the motor area of the brain can be detected at 0.35 T with the contrast mechanism of signal enhancement by extravascular water protons (SEEP). It was also shown that the fMRI experiments at low field strength could be further improved by optimizing TSE parameters during data acquisition and adding a mask image during data processing.

Key words: MRI, fMRI, SEEP, Low field MRI

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