美托拉宗的NMR数据解析

波谱学杂志 ›› 2004, Vol. 21 ›› Issue (1): 93-97.

美托拉宗的NMR数据解析

董建军¹, 吴鸣建^1,2, 张海艳^1,2, 付经国^1,3, 陈涛⁴，赵天增^1,3

1.河南省生物技术开发中心，河南郑州 450002; 2.郑州大学，河南郑州 450052； 
3.河南省科学院化学研究所，河南郑州 450002；4.西安力邦企业，陕西西安750015

收稿日期:2003-06-13 出版日期:2004-03-05 发布日期:2004-03-05

A NMR STUDY OF METOLAZONE

DONG Jian-Jun¹, WU Ming-Jian^1,2, ZHANG Hai-Yan^1,2, FU Jing-Guo^1,3, CHEN Tao⁴, ZHAO Tian-Zeng^1,3

1.Biotechnology Developing Center of Henan Academy of Science, Zhengzhou 450002, China;
2.Zhengzhou University, Zhengzhou 450052, China; 
3.Chemistry Institute, Hennan Academy of Science, Zhengzhou 450002, China； 
4.Libang Pharmaceuticals Corporation Limited, Xi'an 750015, China

Received:2003-06-13 Online:2004-03-05 Published:2004-03-05

摘要/Abstract

摘要：

对美托拉宗进行了1H和13C MNR检测，通过DEPT和HMQC、HMBC等2D NMR技术对其1H和13C NMR数据进行了全归属和详细的解析，并指出其NMR数据特征.

关键词: NMR, 美托拉宗, 构象异构体

Abstract:

Metolazone is a well-known quinazolinone diuretic widely used for the treatment of congestive heart failure and high blood pressure. Metolazone was first synthesized in 1967 with its first detailed pharmacological evaluation done in 1969. Previous results only reported part of its ¹H NMR data, and the detailed elucidation is yet to be performed. In this paper, using a combination of 1D and 2D NMR
techniques, the ¹H and ¹³C NMR spectra of metolazone were completely assigned and analyzed. The characteristics of its NMR data were also discussed.

Key words: NMR, metolazone, conformational isomer

中图分类号:

O641

董建军, 吴鸣建, 张海艳, 付经国, 陈涛, 赵天增. 美托拉宗的NMR数据解析[J]. 波谱学杂志, 2004, 21(1): 93-97.

DONG Jian-Jun, WU Ming-Jian, ZHANG Hai-Yan, FU Jing-Guo, CHEN Tao, ZHAO Tian-Zeng. A NMR STUDY OF METOLAZONE[J]. Chinese Journal of Magnetic Resonance, 2004, 21(1): 93-97.

参考文献

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