波谱学杂志 ›› 2018, Vol. 35 ›› Issue (3): 385-392.doi: 10.11938/cjmr20182620

• 研究简报 • 上一篇    下一篇

卢立康唑的波谱学特征和结构确证

林云良, 高红梅, 李锋, 陈相峰   

  1. 齐鲁工业大学(山东省科学院), 山东省分析测试中心, 山东 济南 250014
  • 收稿日期:2018-03-14 出版日期:2018-09-05 发布日期:2018-08-28
  • 通讯作者: 林云良,Tel:0531-82605343,E-mail:wodekafei@126.com E-mail:wodekafei@126.com
  • 基金资助:
    国家自然科学基金青年科学基金项目(21506119).

Spectral Analysis and Structural Elucidation of Luliconazole

LIN Yun-liang, GAO Hong-mei, LI Feng, CHEN Xiang-feng   

  1. Shandong Analysis and Test Center, Qilu University of Technology(Shandong Academy of Sciences), Ji'nan 250014, China
  • Received:2018-03-14 Online:2018-09-05 Published:2018-08-28

摘要: 用红外吸收光谱、紫外吸收光谱、核磁共振(NMR)波谱(包含1H NMR、13C NMR、DEPT135、1H-1H COSY、1H-13C HMQC和1H-13C HMBC)、质谱、差示扫描量热分析、X-射线粉末衍射和元素分析等方法对卢立康唑进行了结构分析.对卢立康唑所有的1H和13C NMR信号进行了归属,并通过多种谱学技术确证了卢立康唑的结构.

关键词: 核磁共振(NMR), 红外吸收光谱, 质谱, 卢立康唑, 结构确证

Abstract: Infrared spectra, ultraviolet spectra, nuclear magnetic resonance (NMR) spectra (i.e., 1H NMR, 13C NMR, DEPT135, 1H-1H COSY, 1H-13C HMQC and 1H-13C HMBC) and mass spectra of luliconazole were collected and used to characterize the compound. Differential scanning calorimetry, X-ray power diffraction and elementary analysis were also performed. All 1H and 13C NMR signals of the compound were assigned. The structure of the compound was determined.

Key words: nuclear magnetic resonance (NMR), infrared spectroscopy, mass spectroscopy, luliconazole, structure elucidation

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