波谱学杂志 ›› 2014, Vol. 31 ›› Issue (4): 564-571.doi: 10.11938/cjmr20140410

• 研究论文 • 上一篇    下一篇

手性硫脲在DMAP 条件下对布洛芬类药物的NMR 手性识别

马敏山,雷新响*   

  1. 温州大学 化学与材料工程学院, 浙江 温州 325035
  • 收稿日期:2014-02-17 修回日期:2014-10-29 出版日期:2014-12-05 发布日期:2014-12-05
  • 通讯作者: 马敏山 E-mail:youihj1023@gmail.com
  • 作者简介:马敏山(1988-),男,河北保定人,研究生硕士,有机化学专业. *通讯联系人:雷新响,电话:0577-86689197,E-mail:xinxianglei@gmail.com.

Chiral Recognition of Ibuprofen Enatiomers by a Chiral Thiourea in the Presence of DMAP Using NMR

MA Min-shanLEI Xin-xiang*   

  1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China
  • Received:2014-02-17 Revised:2014-10-29 Online:2014-12-05 Published:2014-12-05
  • Contact: Min-Shan MA E-mail:youihj1023@gmail.com
  • About author:*Corresponding author:LEI Xin-xiang, Tel: 0577-86689197, E-mail: xinxianglei@gmail.com.

摘要:

通过1H NMR 研究了手性硫脲对布洛芬类药物的手性识别.在4-二甲氨基吡啶(DMAP)的参与下,硫脲对布洛芬类化合物显示出良好的识别效果,并且布洛芬对映异构体的α-H NMR 信号与硫脲和DMAP 无相互干扰.为了检测硫脲/DMAP 对手性布洛芬对映体纯度的分析能力,测定了若干ee.(对换体过量百分数)值的布洛芬溶液,与理论值吻.

关键词: 核磁共振(NMR), DMAP, 布洛芬, 手性硫脲, 对映体纯度

Abstract:

The chiral recognition of racemic ibuprofen by thiourea was studied using 1H NMR spectroscopy. It was found that, with the participation of DMAP, excellent
recognition of the enantiomers of ibuprofen by thiourea could be achieved, and the process was not affected by the chiral bisthiourea and DMAP. To evaluate the ability of the chiral bisthiourea/DMAP for enantiomeric determination, several ee. values of ibuprofen samples were determined by 1H NMR, and the results coincided with the theoretical value.

Key words: NMR, DMAP, ibuprofen, chiral thiourea, enantiomeric purity

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