Effects of Lipids Signals on Nuclear Overhauser Enhancement Contrast Imaging at 7 T

doi:10.11938/cjmr20150406

Chinese Journal of Magnetic Resonance ›› 2015, Vol. 32 ›› Issue (4): 606-617.doi: 10.11938/cjmr20150406

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Effects of Lipids Signals on Nuclear Overhauser Enhancement Contrast Imaging at 7 T

ZHANG Miao¹， LU Jian-hua²， CAI Cong-bo³， CAI Shu-hui¹*

1. Department of Electronic Science, Xiamen University, Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen 361005, China;
2. Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803, USA;
3. Department of Communication Engineering, Xiamen University, Xiamen 361005, China

Received:2015-02-04 Revised:2015-10-25 Online:2015-12-05 Published:2015-12-05
About author:*Corresponding author： CAI Shu-hui, Tel: +86-592-2183301, E-mail: shcai@xmu.edu.cn.
Supported by:
国家自然科学基金资助项目(U1232212, 81171331)，高等学校博士学科点专项科研基金资助项目(20130121110014)

Abstract

Abstract:

When performing chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) on biological samples at high fields, nuclear Overhauser enhancement (NOE) effects may produce negative signals on the Z-spectra. The NOE-related signal intensity changes have the potential to become a new contrast mechanism. However, the presence of lipids signals within the same chemical shift range may affect the observation of true NOE effect-related signal changes. In this work, we first analyzed the influence of lipid signals on the NOE effects in tissues abundant in lipid via experiments on eggs. Similar experiments were then carried out on healthy rats and rats with brain tumors. The results showed that the presence of large lipid signals could cause pseudo NOE effects and degrade the accuracy of NOE contrast imaging.

Key words: magnetic resonance imaging(MRI), NOE contrast, Lorentzian fitting, fat saturation

CLC Number:

O482.53

ZHANG Miao1， LU Jian-hua2， CAI Cong-bo3， CAI Shu-hui1*. Effects of Lipids Signals on Nuclear Overhauser Enhancement Contrast Imaging at 7 T
[J]. Chinese Journal of Magnetic Resonance, 2015, 32(4): 606-617.

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Effects of Lipids Signals on Nuclear Overhauser Enhancement Contrast Imaging at 7 T

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