Chinese Journal of Magnetic Resonance ›› 2022, Vol. 39 ›› Issue (4): 393-400.doi: 10.11938/cjmr20212955

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Hippocampal Metabolite Alterations in Long-term Insulin-treated Type 1 Diabetes Mellitus Rats Revealed by 1H MRS

Hui XU1,2,Yi-ting WU3,Xu-xia WANG1,2,Yan KANG1,2,Hao LEI1,2,Li-feng GAO3,*()   

  1. 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan (Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences), Wuhan 430071, China
    2. University of Chinese Academy of Sciences, Beijing 100049, China
    3. Department of Medical Imaging, School of Medicine, Jianghan University, Wuhan 430056, China
  • Received:2021-11-04 Online:2022-12-05 Published:2021-12-31
  • Contact: Li-feng GAO E-mail:gao_lifeng@jhun.edu.cn

Abstract:

In this study, 1H magnetic resonance spectroscopy (1H MRS) was used to analyze metabolites in the hippocampus of chronic type 1 diabetes mellitus (T1DM) rats induced by streptozocin and T1DM rats treated with long-term insulin. The results showed that, compared with control rats and insulin-treated T1DM rats, the fasting blood glucose of T1DM rats increased significantly, while the body weight of T1DM rats decreased remarkably (p < 0.05). The contents of myo-inositol (Ins), taurine (Tau) and glutamate (Glu) of T1DM rats were significantly higher than those of control rats (p=0.000, p=0.003, p=0.014, respectively), and the contents of Ins and Tau of insulin-treated T1DM rats were significantly decreased than those in the T1DM diabetic rats (p=0.000, p=0.010, respectively). Contents of Glu and Glx (Glu and glutamine) of insulin-treated T1DM rats were significantly higher than those in the control group (p=0.007, p=0.042, respectively). The metabolite changes of Ins and Tau in hippocampus of T1DM rats are sensitive to insulin treatment.

Key words: 1H MRS, metabolite, hippocampus, type 1 diabetes mellitus, insulin

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