Chinese Journal of Magnetic Resonance ›› 2012, Vol. 29 ›› Issue (2): 216-223.

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Effects of  NMR Parameters on Study of Individual Variations of Plasma-Ibuprofen Interactions

DU Yuan-Yuan1,2, JI Zhu-Sheng1*, LIU Mai-Li1*   

  1. 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance (Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China; 
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
  • Received:2011-05-19 Revised:2011-05-24 Online:2012-06-05 Published:2012-06-05
  • Supported by:

    国家自然科学基金资助项目(20975112).

Abstract:

The interactions between drug and plasma proteins play a major role in drug absorption, metabolism and its efficacy. Previous reports demonstrated that diffusion and relaxation-weighted NMR combined with principal components analysis (PCA) could be used to characterize individual variations of plasma-drug interactions. In this research, using plasma with/without drug ibuprofen (IBP) as model, the NMR parameters including diffusion time, gradient strength for diffusion-weighted NMR and echo time for relaxation-weighted NMR were optimized. The results showed that gradient strength of 1.52×10-3 T/cm~1.90×10-3 T/cm under diffusion time of 0.1 s~0.14 s for diffusion-weighted NMR and echo time of 70 ms~110 ms for relaxation-weighted NMR are optimal for characterizing individual variations of plasma-drug interactions.

Key words: nuclear magnetic resonance(NMR), individual variation, diffusion-weighted NMR, relaxation-weighted NMR, principal components analysis, plasma, ibuprofen

CLC Number: