Chinese Journal of Magnetic Resonance ›› 2020, Vol. 37 ›› Issue (2): 232-240.doi: 10.11938/cjmr20182702

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Proton Magnetic Resonance Spectroscopy in Brain Science Researches

LIU Tao-tao1,2, WANG Jie2, GUO Xiang-yang1   

  1. 1. Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China;
    2. CAS Key Laboratory of Biomedical Magnetic Resonance Analysis, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China
  • Received:2018-12-18 Online:2020-06-05 Published:2019-04-24

Abstract: Nuclear magnetic resonance spectroscopy, especially in vivo proton magnetic resonance spectrum (1H MRS) and proton nuclear magnetic resonance (1H NMR), has been increasingly used in brain science researches. There are pros and cons in 1H MRS and 1H NMR with respect to experiment design, sample preparation and data processing. In this review, we summarized and discussed the recent progresses of these two techniques in the ends of application range, sample preparation, quantification and data analysis. The work will provide a reference and insights for neuroscience researchers who are interested in using magnetic resonance spectroscopy for metabolic studies of the brain.

Key words: nuclear magnetic resonance spectroscopy, in vivo spectrum, brain science, metabolism

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