NMR-Based Analysis of Age-Related Changes of Phosphate Metabolites in Rat Brain

doi:10.11938/cjmr20160206

Abstract

Abstract:

With advances in population aging, age-related diseases have become a global problem. Neurodegenerative disease is one type of leading aging associated diseases, the mechanism of which remains elusive. In the present study, ³¹P NMR spectroscopy was used to characterize alterations of small molecules in rat brain for different age group, and identify alterations of energy associated phosphorylated compounds with aging, which will be helpful for interpreting age-related metabolism in brain. Results showed that energy related metabolite phosphocreatine increased significantly, whereas phosphatidylcholine and phosphorylcholine reduced significantly in aged rat brain. Interestingly, glucose phosphates appeared in aged rat brain. This study demonstrated the alterations of phospholipid metabolism in rat brain with aging, which may help to understand the development of neurodegeneration, and these metabolites may be used as molecular markers for monitoring neurodegenerative disorders.

Key words: ³¹P NMR, metabolism, aging, brain

CLC Number:

O482.53

MA Jing, SUN Peng, LIU Mai-li, ZHANG Xu, ZHANG Xian-rong. NMR-Based Analysis of Age-Related Changes of Phosphate Metabolites in Rat Brain[J]. Chinese Journal of Magnetic Resonance, 2016, 33(2): 236-243.

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