Chinese Journal of Magnetic Resonance ›› 2015, Vol. 32 ›› Issue (2): 150-162.doi: 10.11938/cjmr20150202

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Quadruplex Nucleic Acid Structure Determination by Solution NMR

LIU Chang-dong,ZHU Guang   

  1. Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong
  • Received:2015-03-17 Revised:2015-05-10 Online:2015-06-05 Published:2015-06-05
  • About author:LIU Chang-dong(1979-), male, born in Heilongjiang, PhD., his research focuses on NMR. *Corresponding author: ZHU Guang, Tel: +852-23588705, E-mail: gzhu@ust.hk.

Abstract:

Abstract:G-rich repetitive DNA and RNA sequences can form four-stranded structures named G-quadruplexes. Solution NMR spectroscopy has played a central role in examining G-quadruplex structure, dynamics, and interaction. Here we review NMR methods to study structure and interaction of G-quadruplexes.

Key words: NMR spectroscopy, G-quadruplex, DNA, RNA

CLC Number: