波谱学杂志

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应用核磁共振测定有机化合物绝对构型的方法

滕荣伟1,沈平2,王德祖1,杨崇仁1*   

  1. 1.中国科学院昆明植物研究所,云南昆明 650204;2.沈阳药科大学植物化学室,辽 宁沈阳 110016
  • 收稿日期:2001-08-06 修回日期:2001-10-15 出版日期:2002-06-05 发布日期:2002-06-05
  • 作者简介:滕荣伟(1975-),男,博士,植物化学专业.E- mail: tengrongwei@hotmail.com. *通讯联系人,E-mail: cryang@public.km.yn.cn

METHODS TO DETERMINE THE ABSOLUTE STEREOCHEMISTRY OF ORGANIC COMPOUNDS BY NMR SPECTROSCOPY

TENG Rong-wei1, SHEN Ping2, WANG De-zu1, YANG Chong-ren1*   

  1. 1.Kunming Institute of Botany,  Chinese Academy of Sciences,  Kunming  650204, China; 
    2.Laboratory of Pyhtochemistry,  Shenyan College of Pharmacology,  Shenyang  110016, China
  • Received:2001-08-06 Revised:2001-10-15 Online:2002-06-05 Published:2002-06-05
  • About author:*Correspondence author

摘要:

综述了应用核磁共振测定有机化合物绝对构型的各种方法. 根据方法的原理,将方法分为两类,一类是应用芳环抗磁屏蔽效应测定有机化合物绝对构型的NMR方法,包括M os her法,改进的Mosher法,MPA以及其他AMAs手性试剂方法;另一类是应用配糖位移效应测定有机化合物绝对构型的NMR方法,包括4-O-苯甲酰基葡萄吡喃糖甙方法和岩藻呋喃糖甙 方法等. 本综述包括各种方法的原理,测定绝对构型的步骤等.

关键词: 有机化合物, 绝对构型, 核磁共振

Abstract:

This paper reviews the NMR methods to determine the absolute stereoche mistry of organic compounds.The methods are classified into two types in terms o f the principle in this paper. One applies magnetic anisotropy effect of phenyl orother aryl groups, such as Mosher method, methods utilizing MPA or other AM As chiral reagents. The other type applies glycosylation shift effects due to glyco sylate reactions, such as tetra-O-benzoyl glucosylation method and fucofurano side method. This review deals with the principle,  the determining process, the advantages and disadvantages of each mothod.

Key words: organic compounds, absolute stereochemistry, NMR spe ctroscopy

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