波谱学杂志

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8-O-4′型异木脂素立体构型的测定方法

原忠,李铣   

  1. 沈阳药科大学中药学院28#信箱,辽宁沈阳 110016
  • 收稿日期:2003-03-31 修回日期:2003-05-12 出版日期:2003-09-05 发布日期:2003-09-05
  • 作者简介:原忠(1968-),男,辽宁海城人,博士,副教授, E-mail: yuanzhong15@hotmail.com.

NMR METHODS FOR DETERMINING THE CONFIGURATION OF  8-O-4′NEOLIGNANS

YUAN Zhong, LI Xian   

  1. School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, P.O. Box 28#, Shenyang 110016, China
  • Received:2003-03-31 Revised:2003-05-12 Online:2003-09-05 Published:2003-09-05

摘要:

综述了关于8-O-4′型异木脂素的立体化学方面的研究. 总结了测定8-O-4′型异木脂素的相对构型和绝对构型的常用方法. 1H NMR谱是研究C-7 和C-8间相对构型的常用方法, 若H-7的偶合常数较小,在2.7~5.0 Hz范围内,为赤式;若H-7的偶合常数较大,在6.0~8.6 Hz范围内,则为苏式. 结合NOE差谱以及CD谱的测定,或者Mosher's法,可进一步阐明其绝对构型.

关键词: 核磁共振, 8-O-4′型异木脂素, 立体构型, CD谱, NOE差谱, Mosher's法

Abstract:

The NMR methods for determining the relative and absolute configurations of 8-O-4′Neolignans were reviewed. The relative stereochemistry between C-7
and C-8 should be in the erythro form if the coupling constant between the measured by 1H NMR is small (J=2.7~5.0 Hz). If the coupling constant me
asured is larger (J=6.0~8.6 Hz), the configuration is in the threo form. With the application of NOE difference spectroscopy, CD assay and Mosher's method, the absolute configuration can be determined.

Key words: NMR, 8-O-4′Neolignans, configuration, NOE difference spectroscopy, CD spectroscopy, Mosher's method

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