地塞米松棕榈酸酯的NMR数据解析

波谱学杂志 ›› 2004, Vol. 21 ›› Issue (4): 405-411.

地塞米松棕榈酸酯的NMR数据解析

张海艳^1,2, 吴鸣建^1,2, 董建军², 付经国^2,3, 陈涛⁴，赵天增^2,3

1.郑州大学化学系，河南郑州 450052；2.河南省生物技术开发中心，河南郑州 450002; 
3.河南省科学院化学研究所，河南郑州 450002；4.西安力邦企业，陕西西安 710075

收稿日期:2004-04-19 修回日期:2004-05-31 出版日期:2004-12-05 发布日期:2004-12-05

AN NMR STUDY OF DEXAMETHASONE PALMITATE

ZHANG Hai-Yan^1,2, WU Ming-Jian^1,2, DONG Jian-Jun², FU Jing-Guo^2,3, CHEN Chao⁴, ZHAO Tian-Zeng^2,3

1.Zhengzhou University, Zhengzhou 450052，China;
2.Biotechnology Developing Center of Henan Academy of Science, Zhengzhou 450002, China;
3.Chemistry Institute, Hennan Academy of Science, Zhengzhou 450002,China;
4.Xi'an Libang Corporation, Xi'an 710075, China

Received:2004-04-19 Revised:2004-05-31 Online:2004-12-05 Published:2004-12-05

摘要/Abstract

摘要：

参考地塞米松在D₂O中检测的的¹H、¹⁹F NMR数据、棕榈酸的¹H、¹³C NMR标准图谱数据和Lindeman-Adams经验公式，对地塞米松棕榈酸酯进行了¹H和¹³C MNR检测，通过DEPT和¹H-¹H COSY、HMQC、HMBC等2D NMR技术对该化合物所有的¹H和¹³C NMR信号进行了全归属和详细解析.

关键词: NMR, 归属, 2D NMR, 地塞米松棕榈酸酯

Abstract:

Dexamethasone palmitate incorporated into liposomes (liposteroid) was developed as a targeting antiinflammatory drug (limethason) used mainly for treatment of rheumatoid arthritis. In this study, 1D (¹H, ¹³C NMR and DEPT) and 2D (¹H-¹HCOSY，HMQC and HMBC) NMR spectra of dexamethasone palmitate in chloroform were obtained, assigned and analyzed. The structure of dexamethasone palmitate in chloroform was elucidated by referring to the ¹H and ¹⁹F NMR spectra of dexamethason in the aqueous solution, the standard ¹H and ¹³C NMR spectra of palmitate and the Lindeman-Adams experimental formula.

Key words: NMR, assignments, 2D NMR, dexamethasone palmitate

中图分类号:

O641

张海艳, 吴鸣建, 董建军, 付经国, 陈涛, 赵天增. 地塞米松棕榈酸酯的NMR数据解析[J]. 波谱学杂志, 2004, 21(4): 405-411.

ZHANG Hai-Yan, WU Ming-Jian, DONG Jian-Jun, FU Jing-Guo, CHEN Chao, ZHAO Tian-Zeng. AN NMR STUDY OF DEXAMETHASONE PALMITATE[J]. Chinese Journal of Magnetic Resonance, 2004, 21(4): 405-411.

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