波谱学杂志 ›› 2000, Vol. 17 ›› Issue (5): 362-367.

• 研究论文 • 上一篇    下一篇

苯并二氮杂卓及其衍生物立体化学的1H NMR研究

顼昊2, 许家喜2, 刘雪辉1, 金声2, 崔育新1   

  1. 1. 北京医科大学天然药物及仿生药物国家重点实验室, 医药卫生分析中心, 北京 100083;
    2. 北京大学化学与分子工程学院, 北京 100871
  • 收稿日期:2000-06-19 修回日期:2000-07-24 出版日期:2000-10-05 发布日期:2018-01-11
  • 作者简介:顼昊(1979-),男,97级本科生

1H NMR STUDY ON THE STEREOCHEMISTRY OF 1,3-OXAZINO[3,2-D] [1,5] BENZODIAZEPINE-1-ONES

XU Hao2, XU Jia-xi2, LIU Xue-hui1, JIN Sheng2, CUI Yu-xin1   

  1. 1. National Laboratory of Natural, Biomimetic Drugs, Medical, Healthy Analysis Center, Peking University, Beijing 100083;
    2. College of Chemistry, Molecular Engineering, Peking University, Beijing 100871
  • Received:2000-06-19 Revised:2000-07-24 Online:2000-10-05 Published:2018-01-11

摘要: 应用1H NMR技术对一些以[2+4]环加成方式合成出的苯并二氮杂卓的立体化学进行了研究.利用偶合常数和gNOESY的结果,证明了二氮杂卓七员环的扭船式溶液构象,并与其类似的苯并硫氮杂卓作了比较和讨论.

关键词: 苯并二氮杂卓, 立体化学, 核磁共振氢谱

Abstract: A series of 1,3-oxazino[3,2-d] [1,5] benzodiazepine-1-one derivatives' stereochemistry was studied by 1H NMR. During the 1H NMR experiments, we found out their unique stereochemistry of seven-membered rings. All the discernible hydrogen's chemical shifts were assigned. Their distorted boat conformations were discovered by the related coupling constants and gNOESY results, which were compared with x-ray diffraction result and the conformation of analogous benzothioazepines.

Key words: Benzodiazepine, Stereochemistry, 1H NMR

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