波谱学杂志 ›› 2017, Vol. 34 ›› Issue (1): 115-129.doi: 10.11938/cjmr20170114

• 综述评论 • 上一篇    

固体核磁共振技术在骨基生物材料研究中的应用

李东北, 许帅, 喻志武   

  1. 中国科学院 强磁场科学中心, 安徽 合肥 230031
  • 收稿日期:2016-02-02 修回日期:2017-01-05 出版日期:2017-03-05 发布日期:2017-03-05
  • 通讯作者: 喻志武,Tel:0551-65595167,E-mail:zhiwuyu@hmfl.ac.cn E-mail:zhiwuyu@hmfl.ac.cn
  • 基金资助:
    国家自然科学基金资助项目(21203202)

Application of Solid-State NMR to Bone and Bone Biomaterials

LI Dong-bei, XU Shuai, YU Zhi-wu   

  1. High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, China
  • Received:2016-02-02 Revised:2017-01-05 Online:2017-03-05 Published:2017-03-05

摘要: 骨是人体的结构组织之一,又是重要的造血器官,它在支持和保护体内器官、贮存钙和磷、参与人体代谢和为肌肉提供附着等方面具有重要的作用,因此了解骨的微观结构对预防和治疗骨疾病有重要意义.由于骨形态多样化,无机和有机成分共存,而且骨样品对物理和化学处理十分敏感,因此对其研究存在许多实验困难.与其他表征技术相比,固体核磁共振(NMR)检测对骨样品不需要任何处理,不会破坏其自身结构,可以实现原位检测.另外,骨头中的许多元素(1H、13C、31P、19F、43Ca、29Si、25Mg和87Sr)都是NMR可观察核,因此高分辨固体NMR技术是研究骨基生物材料的强有力工具.该文综述了近年来固体NMR技术在骨基生物材料研究中的应用进展.

关键词: 生物玻璃, 固体核磁共振(solid-state NMR), 骨头, 羟基磷灰石, 生物矿化

Abstract: Bone, as a structural organization and an important hematopoietic organ of the human body, plays critical biological roles in protecting human organs, storing calcium and phosphorus, participating in metabolism regulation and providing attachment sites for muscles. Understanding the microstructure of bone is important for intervention and treatment of bone diseases. However, experimental characterizations of the bone has been hindered by the morphological diversity of the bone, coexistence of organic and inorganic components, and sensitivity of bone samples to physical and chemical treatment. Compared with other techniques, solid-state nuclear magnetic resonance (NMR) can study the bone in-situ without any chemical pretreatment, thus avoiding changing bone structure. In addition, most of the chemical elements in the bone are magnetic resonance detectable, such as 1H, 13C, 31P, 19F, 43Ca, 29Si, 25Mg and 87Sr. Therefore, high resolution solid-state NMR technique provides a powerful tool for structural studies of the bone and bone biomaterials. In this paper, we reviewed the recent progresses in the application of solid-state NMR to bone and bone biomaterials studies.

Key words: bioglass, biomineralization, hydroxyapatite, solid-state NMR, bone

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